CZC-54252 hydrochloride
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Catalog number9567-10
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PricePlease ask
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Size10 mg
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Alternative_nameN-[-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride
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DescriptionCZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC₅₀ values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S
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CAS Number1191911-27-9
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₂H₂₅ClN₆O₄S.HCl
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Molecular Weight541.45
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>40 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent leucine-rich repeat kinase 2 (LRRK2) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID90488950
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SMILESCOC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl
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InChiInChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H
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InChi KeyKWCBHUPLQMUKAF-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameCZC-54252 hydrochloride
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Alternative nameCZC-54252 hydrochloride
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