CZC 54252 Hydrochloride, LRRK2 inhibitor
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Catalog number
SIH-439-25MG
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Price
Please ask
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Size
25 mg
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Stock availabilitIn Stock
In Stock
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CAS number
1191911-27-9
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Description
LRRK2 inhibitor
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Molecular weight
541,5 g/mol
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Primary research fields
Cell Signaling
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Other name
N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide hydrochloride
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C22H26Cl2N6O4S
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 100 mM in DMSO
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Physical appearance
Yellow solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
Refer to PubChem
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Scientific context
CZC 54252 Hydrochloride is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor.
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Bibliography
1. Kramer T., Lo Monte F., Göring S., Okala Amombo G.M., & Schmidt B. (2012) ACS Chem. Neuro. 3(3): 151–160.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of CZC 54252 Hydrochloride (SIH-439), a LRRK2 inhibitor. CAS #: 1191911-27-9. Molecular Formula: C22H26Cl2N6O4S. Molecular Weight: 541.5 g/mol. Chemical structure of CZC 54252 Hydrochloride, a LRRK2 inhibitor (SIH-439). CAS # 1191911-27-9. Molecular Formula: C22H26Cl2N6O4S.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.025
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
LRRK2-DT, LRRK2
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Short name
CZC 54252 Hydrochloride, LRRK2 inhibitor
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Alternative name
CZC 54252 Hydrochloride, leucine-rich repeat kinase 2 suppressor
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Alternative to gene target
leucine-rich repeat kinase 2, LRRK2 and IDBG-27257 and ENSG00000188906 and 120892, transferase activity, Extracellular, Lrrk2 and IDBG-175625 and ENSMUSG00000036273 and 66725, LRRK2 and IDBG-633456 and ENSBTAG00000016260 and 535652
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Gene info
Gene info
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