CZC 54252 Hydrochloride, LRRK2 inhibitor

  • Catalog number
    SIH-439-25MG
  • Price
    Please ask
  • Size
    25 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    1191911-27-9
  • Description
    LRRK2 inhibitor
  • Molecular weight
    541,5 g/mol
  • Primary research fields
    Cell Signaling
  • Other name
    N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide hydrochloride
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C22H26Cl2N6O4S
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble to 100 mM in DMSO
  • Physical appearance
    Yellow solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
  • PubChem number
    Refer to PubChem
  • Scientific context
    CZC 54252 Hydrochloride is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor.
  • Bibliography
    1. Kramer T., Lo Monte F., Göring S., Okala Amombo G.M., & Schmidt B. (2012) ACS Chem. Neuro. 3(3): 151–160.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of CZC 54252 Hydrochloride (SIH-439), a LRRK2 inhibitor. CAS #: 1191911-27-9. Molecular Formula: C22H26Cl2N6O4S. Molecular Weight: 541.5 g/mol. Chemical structure of CZC 54252 Hydrochloride, a LRRK2 inhibitor (SIH-439). CAS # 1191911-27-9. Molecular Formula: C22H26Cl2N6O4S.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.025
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    LRRK2-DT, LRRK2
  • Short name
    CZC 54252 Hydrochloride, LRRK2 inhibitor
  • Alternative name
    CZC 54252 Hydrochloride, leucine-rich repeat kinase 2 suppressor
  • Alternative to gene target
    leucine-rich repeat kinase 2, LRRK2 and IDBG-27257 and ENSG00000188906 and 120892, transferase activity, Extracellular, Lrrk2 and IDBG-175625 and ENSMUSG00000036273 and 66725, LRRK2 and IDBG-633456 and ENSBTAG00000016260 and 535652
Gene info
  • Identity
  • Gene
  • Long gene name
    LRRK2 divergent transcript
  • Locus
  • Discovery year
    2019-08-16
  • Entrez gene record
  • Classification
    • Divergent transcripts
Gene info
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