anti- SH2D1A antibody

• Catalog number
  FNab07819
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
• Immunogen
  SH2 domain protein 1A
• Synonyms
  DSHP, SAP
• Calculated MW
  17 kDa
• Uniprot ID
  O60880
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SH2D1A  
• Gene symbol
  SH2D1A
• Short name
  anti- SH2D1A antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- SH2 domain containing 1A (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  SH2 domain containing 1A, DSHP and EBVS and IMD5 and LYP and MTCP1 and SAP and SAP/SH2D1A and XLP and XLPD and XLPD1, SH2D1A and IDBG-85368 and ENSG00000183918 and 4068, protein binding, Cytoplasm, Sh2d1a and IDBG-141610 and ENSMUSG00000005696 and 20400, SH2D1A and IDBG-630222 and ENSBTAG00000026067 and 613356

Gene info

• Identity
  HGNC:10820
• Gene
  SH2D1A
• Long gene name
  SH2 domain containing 1A
• Synonyms gene
  • IMD5
  • LYP
• Synonyms gene name
  • lymphoproliferative syndrome
  • SH2 domain protein 1A
• Synonyms
  • XLP
  • MTCP1
  • DSHP
  • XLPD
  • EBVS
  • SAP
• Synonyms name
  • Duncan's disease
• GenBank acession
  • AL023657
• Locus
  Xq25
• Discovery year
  1989-06-30
• Entrez gene record
  4068
• Pubmed identfication
  • 9771704
  • 9774102
• RefSeq identity
  • NM_002351
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000022344
• Locus Specific Databases
  • SH2D1Abase: Mutation registry for X-linked lymphoproliferative syndrome (XLP)
  • LRG_106

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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