- Catalog numberCSB-PA021209LB01HU_100ug
- Product nameRabbit Anti Human SH2D1A Antibody-HRP
- Size100ug
- PriceAsk For Price
- Long nameRabbit Antibody against Human SH2D1A, HRP
- Short nameAnti-SH2D1A
- Synonym nameSH2D1A Human Antibody
- HostRabbit, Rabbits
- Species reactivityHuman
- Tested applications recommended dilutionsELISA
- ConjugationHRP
- Antibody isotypeIgG
- UniProt IDO60880
- FormatLiquid, diluted in buffer
- Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Purity>95%
- Purification methodProtein G purified
- Antibody categoryPolyclonal Antibodies
- Immunogen typeRecombinant human SH2 domain-containing protein 1A protein (11-124AA)
- Immunogen speciesHuman
- AliasSH2 domain-containing protein 1A,Duncan disease SH2-protein,Signaling lymphocytic activation molecule-associated protein,SLAM-associated protein,T-c,SH2D1A,DSHP,SAP
- BackgroundCytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
- ClonalityPolyclonal antibody
- Shipping and storageSH2D1A Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
- Short name of the antigenSH2 domain-containing protein 1A
- Alternative to gene target
- [ "SH2 domain containing 1A", "DSHP and EBVS and IMD5 and LYP and MTCP1 and SAP and SAP/SH2D1A and XLP and XLPD and XLPD1", "SH2D1A and IDBG-85368 and ENSG00000183918 and 4068", "protein binding", "Cytoplasm", "Sh2d1a and IDBG-141610 and ENSMUSG00000005696 and 20400", "SH2D1A and IDBG-630222 and ENSBTAG00000026067 and 613356" ]
- Gene targetSH2D1A -
- Identity:HGNC:10820
- Gene:SH2D1A
- Long gene name:SH2 domain containing 1A
- Synonyms gene name:lymphoproliferative syndrome, SH2 domain protein 1A
- Synonyms:XLP, MTCP1DSHPXLPDEBVSSAP
- Discovery year:1989-06-30
- Entrez gene record:4068
- Pubmed identification:9771704, 9774102
- RefSeq identity:NM_002351
- Classification:SH2 domain containing
- VEGA ID:OTTHUMG00000022344
- Gene symbolSH2D1A
- LabelHRP
- label filter
- HRP
- technique filter
- anti human
- Antibody
- Rabbit
- anti
- Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies, rabbit-anti
Gene info
Locus Specific Databases:SH2D1Abase: Mutation registry for X-linked lymphoproliferative syndrome (XLP)LRG_106