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Rabbit Anti Human SH2D1A Antibody-Biotin

  • Catalog number
    CSB-PA021209LD01HU_100ug
  • Product name
    Rabbit Anti Human SH2D1A Antibody-Biotin
  • Size
    100ug
  • Long name
    Rabbit Antibody against Human SH2D1A, Biotin
  • Short name
    Anti-SH2D1A
  • Synonym name
    SH2D1A Human Antibody
  • Host
    Rabbit, Rabbits
  • Species reactivity
    Human
  • Tested applications recommended dilutions
    ELISA
  • Conjugation
    Biotin
  • Antibody isotype
    IgG
  • UniProt ID
    O60880
  • Format
    Liquid, diluted in buffer
  • Buffer composition
    Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • Purity
    >95%
  • Purification method
    Protein G purified
  • Antibody category
    Polyclonal Antibodies
  • Immunogen type
    Recombinant human SH2 domain-containing protein 1A protein (11-124AA)
  • Immunogen species
    Human
  • Alias
    SH2 domain-containing protein 1A,Duncan disease SH2-protein,Signaling lymphocytic activation molecule-associated protein,SLAM-associated protein,T-c,SH2D1A,DSHP,SAP
  • Background
    Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
  • Clonality
    Polyclonal antibody
  • Shipping and storage
    SH2D1A Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
  • Short name of the antigen
    SH2 domain-containing protein 1A
  • Alternative to gene target
    • [ "SH2 domain containing 1A", "DSHP and EBVS and IMD5 and LYP and MTCP1 and SAP and SAP/SH2D1A and XLP and XLPD and XLPD1", "SH2D1A and IDBG-85368 and ENSG00000183918 and 4068", "protein binding", "Cytoplasm", "Sh2d1a and IDBG-141610 and ENSMUSG00000005696 and 20400", "SH2D1A and IDBG-630222 and ENSBTAG00000026067 and 613356" ]
  • Gene target
    SH2D1A -
    • Gene info
    Locus Specific Databases:SH2D1Abase: Mutation registry for X-linked lymphoproliferative syndrome (XLP)LRG_106
  • Gene symbol
    SH2D1A
  • Label
    Biotin
  • label filter
    • Biotin
  • technique filter
    • anti human
    • Antibody
    • Rabbit
    • anti
  • Technique
    anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies, rabbit-anti