CZC-8004

• Catalog number
  B1868-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N2-​[4-​(aminomethyl)​phenyl]​-​5-​fluoro-​N4-​phenyl-2,​4-​pyrimidinediamine
• Description
  CZC-8004 is a pan-specific kinase inhibitor that binds to a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. It inhibits these kinases at low micromolar concentrations and can be coupled to sepharose via its amino side chain for affinity chromatography applications.
• CAS Number
  916603-07-1
• Structure Available
  Yes
• Molecular Formula
  C₁₇H₁₆FN₅
• Molecular Weight
  309.3
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A pan-specific kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  15980598
• PubChem CID Link
• SMILES
  C1=CC=C(C=C1)NC2=NC(=NC=C2F)NC3=CC=C(C=C3)CN
• InChi
  InChI=1S/C17H16FN5/c18-15-11-20-17(22-14-8-6-12(10-19)7-9-14)23-16(15)21-13-4-2-1-3-5-13/h1-9,11H,10,19H2,(H2,20,21,22,23)
• InChi Key
  UKOHFWNBTUJMMN-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  CZC-8004  
• Gene symbol
  KALRN
• Short name
  CZC-8004
• Alternative name
  CZC-8004

Gene info

• Identity
  HGNC:4814
• Gene
  KALRN
• Long gene name
  kalirin RhoGEF kinase
• Synonyms gene
  • HAPIP
• Synonyms gene name
  • huntingtin-associated protein interacting protein (duo)
• Synonyms
  • duo
  • Hs.8004
  • TRAD
  • DUET
  • Kalirin
  • ARHGEF24
• Synonyms name
  • serine/threonine kinase with Dbl and pleckstrin homology domains
• GenBank acession
  • U94190
• Locus
  3q21.1-q21.2
• Discovery year
  1999-01-13
• Entrez gene record
  8997
• Pubmed identfication
  • 9285789
  • 10023074
• RefSeq identity
  • NM_003947
• Classification
  • I-set domain containing
  • Fibronectin type III domain containing
  • Dbl family Rho GEFs
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000125545

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