MMP 14 (MT1-MMP) prodomain, catalytic domain, and hemopexin domain, His-tagged (Recombinant Protein)

• Catalog number
  30 100 122
• Price
  Please ask
• Size
  10 µg/ 50µl

• Protein type
  Recombinant
• Protein subtype
  EC 3.4.24.80
• Protein family
  Matrix Metalloproteinases, matrixins
• Protein description
  MMP14 seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.
• Research area interests
  Diseases associated with MMP14 include Winchester Syndrome and Multicentric Osteolysis, Nodulosis, And Arthropathy. Among its related pathways are Signaling events mediated by focal adhesion kinase and Adhesion
• Package form
  liquid
• Tested applications
  Investigation of MT1-MMP; Generation of active MT1-MMP for progelatinase A activation; Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
• Other names
  Membrane-Type-1 Matrix Metalloproteinase
• Peptide sequence
  SLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVTHHHHHH
• Available target modification
  No
• Expression system
  E.coli
• Product Subtype
  protein fragment
• Active form
  No
• Tag
  His-tagged
• Contents
  50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2.
• Protein purity
  > 80 %
• Molecular weight
  58 kDa
• UniProt number
  P50281
• Gene number
  4323
• Abbreviation
  MMP14
• Full name
  matrix metallopeptidase 14
• Other desciption
  Recombinant soluble pro-MT1-MMP is produced as a periplasmic protein in E. coli. The protein contains prodomain, catalytic domain and hemopexin domain of MT1-MMP
• Purification
  Mentioned in the data sheet
• PubMed citations
  See the data sheet
• Warnings
  For Research Use only.
• Shipping conditions
  dry ice
• Storage condition
  Store at -70°C
• Technical datasheet
  Contact us to receive the datasheet
• Representative figure
• Other products
• Conjugation
  histidine
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  MMP   MT1-MMP   prodomain   catalytic   domain   hemopexin   domain   His-tagged   Protein  
• Gene symbol
  MMP14, MMP24, MMP28, MMP17, MMP15, MMP25, MMP16, MT1H, MT1F, MT1E
• Short name
  MMP 14 (MT1-MMP) prodomain, catalytic domain, hemopexin domain, His-tagged (Recombinant Protein)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Label
  his-tagged
• Species
  Homo sapiens
• Alternative name
  MMP 14 (MT1-MMP) prodomain, catalytic domain, and hemopexin domain, histidine-tagged (Rec. Protein)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:7160
• Gene
  MMP14
• Long gene name
  matrix metallopeptidase 14
• Synonyms gene name
  • matrix metalloproteinase 14 (membrane-inserted)
  • matrix metallopeptidase 14 (membrane-inserted)
• Synonyms
  • MT1-MMP
• Synonyms name
  • membrane type 1 metalloprotease
  • membrane type 1-matrix metalloproteinase
• Locus
  14q11.2
• Discovery year
  1994-11-20
• Entrez gene record
  4323
• Pubmed identfication
  • 8015608
• RefSeq identity
  • NM_004995
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000028704

Gene info

• Identity
  HGNC:7172
• Gene
  MMP24
• Long gene name
  matrix metallopeptidase 24
• Synonyms gene name
  • matrix metalloproteinase 24 (membrane-inserted)
  • matrix metallopeptidase 24 (membrane-inserted)
• Synonyms
  • MT5-MMP
• Synonyms name
  • membrane-type 5 matrix metalloproteinase
• GenBank acession
  • AF131284
• Locus
  20q11.22
• Discovery year
  1999-08-06
• Entrez gene record
  10893
• Pubmed identfication
  • 10363975
• RefSeq identity
  • NM_006690
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000032330

Gene info

• Identity
  HGNC:14366
• Gene
  MMP28
• Long gene name
  matrix metallopeptidase 28
• Synonyms gene name
  • matrix metalloproteinase 28
• Synonyms
  • MMP-25
  • MM28
  • EPILYSIN
  • MMP-28
• GenBank acession
  • AF315683
• Locus
  17q12
• Discovery year
  2001-01-09
• Entrez gene record
  79148
• Pubmed identfication
  • 11121398
  • 11255011
• RefSeq identity
  • NM_024302
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000188387

Gene info

• Identity
  HGNC:7163
• Gene
  MMP17
• Long gene name
  matrix metallopeptidase 17
• Synonyms gene name
  • matrix metalloproteinase 17 (membrane-inserted)
  • matrix metallopeptidase 17 (membrane-inserted)
• Synonyms
  • MT4-MMP
• GenBank acession
  • X89576
• Locus
  12q24.33
• Discovery year
  1996-11-13
• Entrez gene record
  4326
• Pubmed identfication
  • 9878265
• RefSeq identity
  • NM_016155
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000168050

Gene info

• Identity
  HGNC:7161
• Gene
  MMP15
• Long gene name
  matrix metallopeptidase 15
• Synonyms gene name
  • matrix metalloproteinase 15 (membrane-inserted)
  • matrix metallopeptidase 15 (membrane-inserted)
• Synonyms
  • MT2-MMP
  • MTMMP2
  • SMCP-2
• GenBank acession
  • Z48482
• Locus
  16q21
• Discovery year
  1996-11-13
• Entrez gene record
  4324
• Pubmed identfication
  • 9070935
  • 9119382
• RefSeq identity
  • NM_002428
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000133466

Gene info

• Identity
  HGNC:14246
• Gene
  MMP25
• Long gene name
  matrix metallopeptidase 25
• Synonyms gene
  • MMPL1
  • MMP20
• Synonyms gene name
  • matrix metalloproteinase 25
  • matrix metallopeptidase-like 1
• Synonyms
  • MT6-MMP
• GenBank acession
  • AF145442
• Locus
  16p13.3
• Discovery year
  2000-12-13
• Entrez gene record
  64386
• Pubmed identfication
  • 10628838
  • 10706098
• RefSeq identity
  • NM_022468
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000177475

Gene info

• Identity
  HGNC:7162
• Gene
  MMP16
• Long gene name
  matrix metallopeptidase 16
• Synonyms gene
  • C8orf57
• Synonyms gene name
  • matrix metalloproteinase 16 (membrane-inserted)
  • chromosome 8 open reading frame 57
  • matrix metallopeptidase 16 (membrane-inserted)
• Synonyms
  • MT3-MMP
  • DKFZp761D112
• GenBank acession
  • D85511
• Locus
  8q21.3
• Discovery year
  1996-11-13
• Entrez gene record
  4325
• Pubmed identfication
  • 7559440
• RefSeq identity
  • NM_005941
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000163769

Gene info

• Identity
  HGNC:7400
• Gene
  MT1H
• Long gene name
  metallothionein 1H
• Synonyms gene
  • MT1
• GenBank acession
  • BC008408
• Locus
  16q13
• Discovery year
  1990-09-10
• Entrez gene record
  4496
• Pubmed identfication
  • 2286373
  • 8049263
• RefSeq identity
  • NM_005951
• Classification
  • Metallothioneins
• VEGA ID
  OTTHUMG00000133283

Gene info

• Identity
  HGNC:7398
• Gene
  MT1F
• Long gene name
  metallothionein 1F
• Synonyms gene
  • MT1
• GenBank acession
  • BC029453
• Locus
  16q13
• Discovery year
  1990-09-10
• Entrez gene record
  4494
• Pubmed identfication
  • 6089206
  • 2581970
• RefSeq identity
  • NM_005949
• Classification
  • Metallothioneins
• VEGA ID
  OTTHUMG00000176838

Gene info

• Identity
  HGNC:7397
• Gene
  MT1E
• Long gene name
  metallothionein 1E
• Synonyms gene
  • MT1
• Synonyms
  • MTD
• GenBank acession
  • BC009699
• Locus
  16q13
• Discovery year
  1990-09-10
• Entrez gene record
  4493
• Pubmed identfication
  • 6089206
  • 2581970
• RefSeq identity
  • NM_175617
• Classification
  • Metallothioneins
• VEGA ID
  OTTHUMG00000133014

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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