Human CellExp™ LOXL2, human recombinant

• Catalog number
  P1084-50
• Price
  Please ask
• Size
  50 µg

• Synonyms
  Lysyl oxidase homolog 2, LOXL2
• Alternative_names
  Lysyl oxidase homolog 2, LOXL2
• Description
  Mediates the post-translational oxidative deamination of lysine residues on target proteins.
• Recombinant
  Yes
• Source
  HEK 293 cells
• Purity by SDS PAGE
  >75%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 1 EU/ug
• Molecular Weight
  111.6 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
• Reconstitution Instructions
  Reconstitute in sterile deionized water to a concentration of 50 ug/ml.
• Background Information
  Lysyl oxidase homolog 2 also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   LOXL2  
• Gene symbol
  LOXL2
• Short name
  CellExp™ LOXL2, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ lysyl oxidase-like 2, H. sapiens Rec.
• Alternative technique
  rec
• Alternative to gene target
  lysyl oxidase-like 2, LOR2 and WS9-14, LOXL2 and IDBG-11841 and ENSG00000134013 and 4017, oxidoreductase activity, nuclei, Loxl2 and IDBG-177377 and ENSMUSG00000034205 and 100862072,94352, LOXL2 and IDBG-635071 and ENSBTAG00000006214 and 532684

Gene info

• Identity
  HGNC:6666
• Gene
  LOXL2
• Long gene name
  lysyl oxidase like 2
• Synonyms gene name
  • lysyl oxidase-like 2
• Synonyms
  • WS9-14
  • LOR
• GenBank acession
  • U89942
• Locus
  8p21.3
• Discovery year
  1997-11-10
• Entrez gene record
  4017
• Pubmed identfication
  • 9722957
• Classification
  • Scavenger receptor cysteine rich domain containing
• VEGA ID
  OTTHUMG00000163797

MeSH Data

• Name
  Cloning, Molecular
• Concept
  Scope note: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
• Tree numbers
  • E05.393.220
• Qualifiers
  drug effects, methods, radiation effects

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