gentaur logogentaur logo
x

Rabbit Anti Human LOXL2 Antibody-Biotin

  • Catalog number
    CSB-PA897283LD01HU_50ug
  • Product name
    Rabbit Anti Human LOXL2 Antibody-Biotin
  • Size
    50ug
  • Long name
    Rabbit Antibody against Human LOXL2, Biotin
  • Short name
    Anti-LOXL2
  • Synonym name
    LOXL2 Human Antibody
  • Host
    Rabbit, Rabbits
  • Species reactivity
    Human
  • Tested applications recommended dilutions
    ELISA
  • Conjugation
    Biotin
  • Antibody isotype
    IgG
  • UniProt ID
    Q9Y4K0
  • Format
    Liquid, diluted in buffer
  • Buffer composition
    Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • Purity
    >95%
  • Purification method
    Protein G purified
  • Antibody category
    Polyclonal Antibodies
  • Immunogen type
    Recombinant Human Lysyl oxidase homolog 2 protein (27-121AA)
  • Immunogen species
    Human
  • Alias
    Lysyl oxidase homolog 2,Lysyl oxidase-like protein 2,Lysyl oxidase-related protein 2,Lysyl oxidase-related protein WS9-14,LOXL2
  • Background
    Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
  • Clonality
    Polyclonal antibody
  • Shipping and storage
    LOXL2 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
  • Short name of the antigen
    Lysyl oxidase homolog 2
  • Alternative to gene target
    • [ "lysyl oxidase-like 2", "LOR2 and WS9-14", "LOXL2 and IDBG-11841 and ENSG00000134013 and 4017", "oxidoreductase activity", "nuclei", "Loxl2 and IDBG-177377 and ENSMUSG00000034205 and 100862072,94352", "LOXL2 and IDBG-635071 and ENSBTAG00000006214 and 532684" ]
  • Gene target
    LOXL2 -
    • Gene info
  • Gene symbol
    LOXL2
  • Label
    Biotin
  • label filter
    • Biotin
  • technique filter
    • anti human
    • Antibody
    • Rabbit
    • anti
  • Technique
    anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies, rabbit-anti