TAK-632

Alternative_name

N-(7-cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide
Description

A selective pan-RAF inhibitor with IC₅₀ Values: 2.4 nM (BRAF V600E); 1.4 nM (C-RAF); 160 nM (VEGFR). TAK-632 displays significant cellular activity against mutated BRAF or mutated NRAS cancer cell lines.
CAS Number

1228591-30-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₇H₁₈F₄N₄O₃S
Molecular Weight

554.51
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>50 mg/ml)
Handling

Protect from air and light
Tag Line

A highly potent and selective pan-RAF inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
SMILES

O=C(NC1=C(F)C=CC(OC2=CC=C(N=C(NC(C3CC3)=O)S4)C4=C2C#N)=C1)CC5=CC(C(F)(F)F)=CC=C5
InChi

InChI=1S/C27H18F4N4O3S/c28-19-7-6-17(12-21(19)33-23(36)11-14-2-1-3-16(10-14)27(29,30)31)38-22-InChI=1S/C27H18F4N4O3S/c28-19-7-6-17(12-21(19)33-23(36)11-14-2-1-3-16(10-14)27(29,30)31)38-22-9-8-20-24(18(22)13-32)39-26(34-20)35-25(37)15-4-5-15/h1-3,6-10,12,15H,4-5,11H2,(H,33,36)(H,34,35,37)
InChi Key

OJFKUJDRGJSAQB-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes