TAK 165
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Catalog number1951-5
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PricePlease ask
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Size5 mg
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Alternative_name(E)-4-((4-)1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-trifluoromethyl)oxazole; Mubritinib
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DescriptionCell-permeable. A potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase (IC₅₀ = 6 nM). Displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. TAK 165 inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo.
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CAS Number366017-09-6
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₅H₂₃F₃N₄O₂
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Molecular Weight468.47
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~25 mg/ml) or EtOH (~ 1.7 mg/ml)
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HandlingProtect from light and air
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Tag LineA potent HER2 tyrosine kinase inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life48 months
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MDL NumberMFCD09954135
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PubChem CID6444692
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SMILESC1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F
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InChiInChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
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InChi KeyZTFBIUXIQYRUNT-MDWZMJQESA-N
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MSDS AvailableYes
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Gene target
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Gene symbolCDK9
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Short nameTAK 165
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Alternative nameTAK 165
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Gene info
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Identity
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Gene
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Long gene namecyclin dependent kinase 9
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Synonyms gene
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Synonyms gene name
- cyclin-dependent kinase 9 (CDC2-related kinase)
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-04-29
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Entrez gene record
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Pubmed identfication
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Classification
- Cyclin dependent kinases
- P-TEFb complex subunits
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VEGA ID