TAK 165

Alternative_name

(E)-4-((4-)1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-trifluoromethyl)oxazole; Mubritinib
Description

Cell-permeable. A potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase (IC₅₀ = 6 nM). Displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. TAK 165 inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo.
CAS Number

366017-09-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₅H₂₃F₃N₄O₂
Molecular Weight

468.47
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~25 mg/ml) or EtOH (~ 1.7 mg/ml)
Handling

Protect from light and air
Tag Line

A potent HER2 tyrosine kinase inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

48 months
MDL Number

MFCD09954135
PubChem CID

6444692
PubChem CID Link
SMILES

C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F
InChi

InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
InChi Key

ZTFBIUXIQYRUNT-MDWZMJQESA-N
Data Sheet Link
MSDS Available

Yes