TAK-063

Alternative_name

1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
Description

TAK-063 is a highly potent, cell-permeable PDE10A inhibitor (IC₅₀ = 0.30 nM) with excellent selectivity (>15000-fold selective over other PDEs).
CAS Number

1238697-26-1
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₃H₁₇FN₆O₂
Molecular Weight

428.42
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>20 mg/ml)
Handling

Protect from air and light
Tag Line

A highly potent, cell-permeable PDE10A inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

46848915
PubChem CID Link
SMILES

COC1=CN(N=C(C1=O)C2=CC=NN2C3=CC=CC=C3)C4=C(C=C(C=C4)N5C=CC=N5)F
InChi

InChI=1S/C23H17FN6O2/c1-32-21-15-29(19-9-8-17(14-18(19)24)28-13-5-11-25-28)27-22(23(21)31)20-10-12-26-30(20)16-6-3-2-4-7-16/h2-15H,1H3
InChi Key

KVHRYLNQDWXAGI-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes