SGI-7079

Alternative_name

2-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acetonitrile
Description

SGI-7079 is a potent and selective Axl inhibitor with potential anticancer activity. SGI-7079 significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC₅₀ of 0.43 or 0.16 μM, respectively
CAS Number

1239875-86-5
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₆H₂₆FN₇
Molecular Weight

455.54
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent and selective Axl inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

46870258
PubChem CID Link
SMILES

CC1=CNC2=NC(=NC(=C12)C3=CC(=CC=C3)CC#N)NC4=CC(=C(C=C4)N5CCN(CC5)C)F
InChi

InChI=1S/C26H26FN7/c1-17-16-29-25-23(17)24(19-5-3-4-18(14-19)8-9-28)31-26(32-25)30-20-6-7-22(21(27)15-20)34-12-10-33(2)11-13-34/h3-7,14-16H,8,10-13H2,1-2H3,(H2,29,30,31,32)
InChi Key

BCFKACXAIBEPKR-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes