SGI-1027
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Catalog number2726-25
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PricePlease ask
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Size25 mg
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Alternative_nameN-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
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DescriptionSGI-1027 is a selective DNA methyltransferase (DNMT) inhibitor. Inhibits DNMT1, DNMT3A, and DNMT3B with IC₅₀ values of 6, 8, and 7.5 µM, respectively. Treatment of different cancer cell lines with SGI-1027 results in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B
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CAS Number1020149-73-8
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Structure AvailableY
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Salt FormNo
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Molecular FormulaC₂₇H₂₃N₇O
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Molecular Weight461.52
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Cell PermeableYes
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Purity³98%
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SolubilitiesDMSO (~20 mg/ml)
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HandlingProtect from air and light
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Tag LineA selective DNA methyltransferase (DNMT) inhibitor
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Storage Condition-20°C
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Shipping ConditionGel pack
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Shelf Life36 months
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PubChem CID24858111
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SMILESCC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54
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InChiInChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34)
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InChi KeyQSYLKMKIVWJAAK-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolCHGB
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Short nameSGI-1027
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Alternative nameSGI-1027
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Gene info
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Identity
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Gene
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Long gene namechromogranin B
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Synonyms gene
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Synonyms gene name
- secretogranin 1
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Synonyms
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Synonyms name
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Locus
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Discovery year1990-07-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Granins
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VEGA ID