SGI-1027

  • Catalog number
    2726-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
  • Description
    SGI-1027 is a selective DNA methyltransferase (DNMT) inhibitor. Inhibits DNMT1, DNMT3A, and DNMT3B with IC₅₀ values of 6, 8, and 7.5 µM, respectively. Treatment of different cancer cell lines with SGI-1027 results in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B
  • CAS Number
    1020149-73-8
  • Structure Available
    Y
  • Salt Form
    No
  • Molecular Formula
    C₂₇H₂₃N₇O
  • Molecular Weight
    461.52
  • Cell Permeable
    Yes
  • Purity
    ³98%
  • Solubilities
    DMSO (~20 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A selective DNA methyltransferase (DNMT) inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    Gel pack
  • Shelf Life
    36 months
  • PubChem CID
    24858111
  • SMILES
    CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54
  • InChi
    InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34)
  • InChi Key
    QSYLKMKIVWJAAK-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    CHGB
  • Short name
    SGI-1027
  • Alternative name
    SGI-1027
Gene info
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