SGI-1776

• Catalog number
  2554-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
• Description
  SGI-1776 is a potent and ATP-competitive Pim kinase inhibitor (IC₅₀’s = 7, 363, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively). SGI-1776 also inhibits FLT3 (IC₅₀ = 44 nM). Induces apoptosis in chronic lymphocytic leukemia cells.
• CAS Number
  1025065-69-3
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₀H₂₂F₃N₅O
• Molecular Weight
  405.42
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>75 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A Pim kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  24 months
• PubChem CID
  24795070
• PubChem CID Link
• SMILES
  CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
• InChi
  InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)
• InChi Key
  MHXGEROHKGDZGO-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SGI-1776  
• Gene symbol
  CHGB
• Short name
  SGI-1776
• Alternative name
  SGI-1776

Gene info

• Identity
  HGNC:1930
• Gene
  CHGB
• Long gene name
  chromogranin B
• Synonyms gene
  • SCG1
• Synonyms gene name
  • secretogranin 1
• Synonyms
  • SgI
• Synonyms name
  • secretogranin B
• Locus
  20p12.3
• Discovery year
  1990-07-06
• Entrez gene record
  1114
• Pubmed identfication
  • 3608978
• RefSeq identity
  • NM_001819
• Classification
  • Granins
• VEGA ID
  OTTHUMG00000031821

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