AKR1C3 Inhibitor II
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Catalog number2404-5
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PricePlease ask
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Size5 mg
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Alternative_name1-(4-((2-Methylpiperidin-1-yl)sulfonyl)phenyl)pyrrolidin-2-one
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DescriptionA highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 94 nM). Displays much weaker inhibitory activity against AKR1C1, AKR1C2 and AKR1C4 (IC₅₀ >30 µM). Does not display any COX (cyclooxygenase) inhibition at 10 µM in whole blood assay.
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Structure AvailableYes
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Peptide sequenceNo
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Salt FormNo
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Molecular FormulaC₁₆H₂₂N₂O₃S
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Molecular Weight322.42
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA highly potent and selective AKR1C3 inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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SMILESO=C1N(C2=CC=C(S(=O)(N3C(C)CCCC3)=O)C=C2)CCC1
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InChiInChI=1S/C16H22N2O3S/c1-13-5-2-3-12-18(13)22(20,21)15-9-7-14(8-10-15)17-11-4-6-16(17)19/h7-10,13H,2-6,11-12H2,1H3
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InChi KeyKCSTYGPHSVKBQP-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolAKR1C3
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Short nameAKR1C3 Inhibitor II
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Alternative namealdo-keto reductase family 1, member complement component 3 (3-a hydroxysteroid dehydrogenase, classification II) suppressor II
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Alternative to gene targetaldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), DD3 and DDX and HA1753 and HAKRB and HAKRe and hluPGFS and HSD17B5 and PGFS, AKR1C3 and IDBG-47964 and ENSG00000196139 and 8644, oxidoreductase activity, nuclei
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Gene info
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Identity
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Gene
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Long gene namealdo-keto reductase family 1 member C3
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Synonyms gene
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Synonyms gene name
- hydroxysteroid (17-beta) dehydrogenase 5
- aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-09-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Aldo-keto reductases
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VEGA ID