Butyrolactone 3
-
Catalog numberB2817-5
-
PricePlease ask
-
Size5 mg
-
-
Alternative_namerel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid
-
DescriptionButyrolactone 3 is an inhibitor of histone acetyltransferase (HAT) Gcn5. Gcn5 acetylates histones H2B and H3. Butyrolactone 3 inhibits Gcn5 with an IC₅₀ value of 100 μM. It has an affinity to the Gcn5 enzyme similar to its substrate, histone H3. It inhibits pre-mRNA splicing with an IC₅₀ of 0.5 mM.
-
CAS Number778649-18-6
-
Structure AvailableTrue
-
Salt FormFalse
-
Molecular FormulaC₉H₁₂O₄
-
Molecular Weight184.19
-
Cell PermeableFalse
-
Purity≥95%
-
Solubilities~2 mg/ml in PBS, pH 7.2 in 0, ~14 mg/ml in ethanol and DMSO in 0
-
HandlingDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
-
Tag LineAn inhibitor of histone acetyltransferase Gcn5
-
Storage Condition-20ºC
-
Shipping ConditionRT
-
Shelf Life36 months
-
PubChem CID10081070
-
SMILESCCCC1C(C(=C)C(=O)O1)C(=O)O
-
InChiInChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m0/s1
-
InChi KeySRQUTZJZABSZRQ-NKWVEPMBSA-N
-
MSDS AvailableTrue
-
Gene target
-
Short nameButyrolactone 3
-
Alternative nameButyrolactone 3
-