Butyrolactone 3

• Catalog number
  B2817-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  rel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid
• Description
  Butyrolactone 3 is an inhibitor of histone acetyltransferase (HAT) Gcn5. Gcn5 acetylates histones H2B and H3. Butyrolactone 3 inhibits Gcn5 with an IC₅₀ value of 100 μM. It has an affinity to the Gcn5 enzyme similar to its substrate, histone H3. It inhibits pre-mRNA splicing with an IC₅₀ of 0.5 mM.
• CAS Number
  778649-18-6
• Structure Available
  True
• Salt Form
  False
• Molecular Formula
  C₉H₁₂O₄
• Molecular Weight
  184.19
• Cell Permeable
  False
• Purity
  ≥95%
• Solubilities
  ~2 mg/ml in PBS, pH 7.2 in 0, ~14 mg/ml in ethanol and DMSO in 0
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  An inhibitor of histone acetyltransferase Gcn5
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• PubChem CID
  10081070
• PubChem CID Link
• SMILES
  CCCC1C(C(=C)C(=O)O1)C(=O)O
• InChi
  InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m0/s1
• InChi Key
  SRQUTZJZABSZRQ-NKWVEPMBSA-N
• Data Sheet Link
• MSDS Available
  True

• Gene target
  Butyrolactone  
• Short name
  Butyrolactone 3
• Alternative name
  Butyrolactone 3

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