N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX 01294

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Cas number

1197196-48-7
Chemical s molecular weight

485.67
Chemical s main applications

N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX-01294, is selective G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor.
Chemical s category

Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Other name

7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine; UNC 0224
Chemical s formula

C26H43N7O2
Physical properties

No Data Available
Melting temperature

No Data Available
Boiling temperature

No Data Available
Chemical s soluble in

No Data Available
Stability conditions

No Data Available
Storage

No Data Available
Chemical s specifications
Description

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3. In formulas, the group is often abbreviated Me. Such hydrocarbon groups occur in many organic compounds. It is a very stable group in most molecules. While the methyl group is usually part of a larger molecule, it can be found on its own in any of three forms anion, cation or radical. The anion has eight valence electrons, the radical seven and the cation six. All three forms are highly reactive and rarely observed,

Gene target

N-Debenzyl-N-methyl-O-demethyl-O 3-dimethylaminopropyl BIX 01294
Gene symbol

H3C15, GH1, CENPO, H4C15, POFUT1, POLM, NRAS, SDR9C7, GNAO1, SDC3
Short name

N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX 01294
Alternative name

N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX 01294

Identity

HGNC:20505
Gene

H3C15
Long gene name

H3 clustered histone 15
Synonyms gene
- HIST2H3A
Synonyms gene name
- histone 2, H3a
- histone cluster 2, H3a
- histone cluster 2 H3 family member a
Synonyms
- H3/n
- H3/o
GenBank acession
- AF531305
Locus

1q21.2
Discovery year

2003-02-19
Entrez gene record

333932
Pubmed identfication
- 12408966
- 15527963
Classification
- H3 histones
VEGA ID

OTTHUMG00000012094

Identity

HGNC:29607
Gene

H4C15
Long gene name

H4 clustered histone 15
Synonyms gene
- HIST2H4B
Synonyms gene name
- histone 2, H4b
- histone cluster 2, H4b
- histone cluster 2 H4 family member b
Synonyms
- H4/o
GenBank acession
- BC108260
Locus

1q21.2
Discovery year

2006-06-12
Entrez gene record

554313
Pubmed identfication
- 15527963
RefSeq identity
- NM_001034077
Classification
- H4 histones
VEGA ID

OTTHUMG00000188201

Identity

HGNC:14988
Gene

POFUT1
Long gene name

protein O-fucosyltransferase 1
Synonyms
- O-FUT
- O-Fuc-T
- KIAA0180
- FUT12
Synonyms name
- peptide-O-fucosyltransferase
- GDP-fucose protein O-fucosyltransferase 1
GenBank acession
- AF375884
Locus

20q11.21
Discovery year

2001-10-29
Entrez gene record

23509
Pubmed identfication
- 9023546
- 9525914
RefSeq identity
- NM_015352
Classification
- MicroRNA protein coding host genes
- Fucosyltransferases
VEGA ID

OTTHUMG00000133268

Identity

HGNC:7989
Gene

NRAS
Long gene name

NRAS proto-oncogene, GTPase
Synonyms gene name
- neuroblastoma RAS viral (v-ras) oncogene homolog
- neuroblastoma RAS viral oncogene homolog
Synonyms
- N-ras
GenBank acession
- BC005219
Locus

1p13.2
Discovery year

2001-06-22
Entrez gene record

4893
Pubmed identfication
- 6705568
- 11524732
RefSeq identity
- NM_002524
Classification
- RAS type GTPase family
VEGA ID

OTTHUMG00000012059
Locus Specific Databases
- NRASbase: Mutation registry for autoimmune lymphoproliferative syndrome type IV
- LRG_92

Identity

HGNC:4389
Gene

GNAO1
Long gene name

G protein subunit alpha o1
Synonyms gene name
- guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Synonyms
- G-ALPHA-o
Locus

16q13
Discovery year

1988-04-24
Entrez gene record

2775
Pubmed identfication
- 1899283
- 11395521
RefSeq identity
- NM_020988
Classification
- G protein subunits alpha, group i
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000133241