Di-O-glycinoylcurcumin Dihydrochloride

• Catalog number
  D455700
• Price
  Please ask
• Size
  100 mg

• Chemical available in other sizes
  Please inquire size and price
• Stock availability
  In Stock
• Cas number
  1322544-82-0
• Chemical s molecular weight
  555.4
• Chemical s main applications
  Di-O-glycinoylcurcumin Dihydrochloride is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disease (Chem. and Eng. News 90(31), 44 (2012)).
• Chemical s category
  Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Other name
  ((1E,6E)-3,5-Dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-4,1-phenylene) bis(2-aminoacetate) Dihydrochloride
• Chemical s formula
  C25H28Cl2N2O8
• Physical properties
  Yellow Solid
• Melting temperature
  >127ºC (dec.)
• Boiling temperature
  No Data Available
• Chemical s soluble in
  DMSO (Slightly), Methanol (Slightly)
• Stability conditions
  No Data Available
• Storage
  Amber Vial, -20°C Freezer, Under inert atmosphere
• Chemical s specifications

• Gene target
  Di-O-glycinoylcurcumin   Dihydrochloride  
• Gene symbol
  CENPO, H4C15, POFUT1, SDR9C7, GNAO1, H3C15, FABP3, H2BC19P, OGT, AOPEP
• Short name
  Di-O-glycinoylcurcumin Dihydrochloride
• Alternative name
  Di-O-glycinoylcurcumin Dihydrochloride

Gene info

• Identity
  HGNC:28152
• Gene
  CENPO
• Long gene name
  centromere protein O
• Synonyms
  • MGC11266
  • CENP-O
• GenBank acession
  • AK027859
• Locus
  2p23.3
• Discovery year
  2006-06-15
• Entrez gene record
  79172
• Pubmed identfication
  • 16622420
  • 16622419
• RefSeq identity
  • NM_024322
• Classification
  • Constitutive centromere associated network
• VEGA ID
  OTTHUMG00000125525

Gene info

• Identity
  HGNC:29607
• Gene
  H4C15
• Long gene name
  H4 clustered histone 15
• Synonyms gene
  • HIST2H4B
• Synonyms gene name
  • histone 2, H4b
  • histone cluster 2, H4b
  • histone cluster 2 H4 family member b
• Synonyms
  • H4/o
• GenBank acession
  • BC108260
• Locus
  1q21.2
• Discovery year
  2006-06-12
• Entrez gene record
  554313
• Pubmed identfication
  • 15527963
• RefSeq identity
  • NM_001034077
• Classification
  • H4 histones
• VEGA ID
  OTTHUMG00000188201

Gene info

• Identity
  HGNC:14988
• Gene
  POFUT1
• Long gene name
  protein O-fucosyltransferase 1
• Synonyms
  • O-FUT
  • O-Fuc-T
  • KIAA0180
  • FUT12
• Synonyms name
  • peptide-O-fucosyltransferase
  • GDP-fucose protein O-fucosyltransferase 1
• GenBank acession
  • AF375884
• Locus
  20q11.21
• Discovery year
  2001-10-29
• Entrez gene record
  23509
• Pubmed identfication
  • 9023546
  • 9525914
• RefSeq identity
  • NM_015352
• Classification
  • MicroRNA protein coding host genes
  • Fucosyltransferases
• VEGA ID
  OTTHUMG00000133268

Gene info

• Identity
  HGNC:29958
• Gene
  SDR9C7
• Long gene name
  short chain dehydrogenase/reductase family 9C member 7
• Synonyms gene name
  • short chain dehydrogenase/reductase family 9C, member 7
• Synonyms
  • SDR-O
  • RDHS
• GenBank acession
  • AY044434
• Locus
  12q13.3
• Discovery year
  2008-12-22
• Entrez gene record
  121214
• Pubmed identfication
  • 12234675
  • 19027726
• RefSeq identity
  • NM_148897
• Classification
  • Short chain dehydrogenase/reductase superfamily
• VEGA ID
  OTTHUMG00000171004

Gene info

• Identity
  HGNC:4389
• Gene
  GNAO1
• Long gene name
  G protein subunit alpha o1
• Synonyms gene name
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
• Synonyms
  • G-ALPHA-o
• Locus
  16q13
• Discovery year
  1988-04-24
• Entrez gene record
  2775
• Pubmed identfication
  • 1899283
  • 11395521
• RefSeq identity
  • NM_020988
• Classification
  • G protein subunits alpha, group i
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133241

Gene info

• Identity
  HGNC:20505
• Gene
  H3C15
• Long gene name
  H3 clustered histone 15
• Synonyms gene
  • HIST2H3A
• Synonyms gene name
  • histone 2, H3a
  • histone cluster 2, H3a
  • histone cluster 2 H3 family member a
• Synonyms
  • H3/n
  • H3/o
• GenBank acession
  • AF531305
• Locus
  1q21.2
• Discovery year
  2003-02-19
• Entrez gene record
  333932
• Pubmed identfication
  • 12408966
  • 15527963
• Classification
  • H3 histones
• VEGA ID
  OTTHUMG00000012094

Gene info

• Identity
  HGNC:3557
• Gene
  FABP3
• Long gene name
  fatty acid binding protein 3
• Synonyms gene
  • MDGI
  • FABP11
• Synonyms gene name
  • fatty acid binding protein 11
  • fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
  • fatty acid binding protein 3, muscle and heart
• Synonyms
  • H-FABP
  • O-FABP
• Synonyms name
  • mammary-derived growth inhibitor
• GenBank acession
  • U57623
• Locus
  1p35.2
• Discovery year
  1991-08-06
• Entrez gene record
  2170
• Pubmed identfication
  • 8661024
• RefSeq identity
  • NM_004102
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000003797

Gene info

• Identity
  HGNC:20517
• Gene
  H2BC19P
• Long gene name
  H2B clustered histone 19, pseudogene
• Synonyms gene
  • H2BFO
  • HIST2H2BD
• Synonyms gene name
  • histone 2, H2bd
  • H2B histone family, member O
  • histone cluster 2, H2bd (pseudogene)
  • histone cluster 2 H2B family member d (pseudogene)
• Synonyms
  • H2B/s
  • H2B/o
• GenBank acession
  • AY131978
• Locus
  1q21.2
• Discovery year
  2003-02-20
• Entrez gene record
  337874
• Pubmed identfication
  • 12408966
  • 15527963
• RefSeq identity
  • NG_001226
• Classification
  • H2B histones
• VEGA ID
  OTTHUMG00000035827

Gene info

• Identity
  HGNC:8127
• Gene
  OGT
• Long gene name
  O-linked N-acetylglucosamine (GlcNAc) transferase
• Synonyms gene name
  • O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
• Synonyms
  • O-GLCNAC
  • HRNT1
  • MGC22921
  • FLJ23071
  • OGT1
• Synonyms name
  • UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
• GenBank acession
  • U77413
• Locus
  Xq13.1
• Discovery year
  1998-12-03
• Entrez gene record
  8473
• Pubmed identfication
  • 9083068
• RefSeq identity
  • NM_003605
  • NM_181672
• Classification
  • O-linked N-acetylglucosaminyltransferases
  • NSL histone acetyltransferase complex
  • Tetratricopeptide repeat domain containing
• VEGA ID
  OTTHUMG00000033316
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:1361
• Gene
  AOPEP
• Long gene name
  aminopeptidase O (putative)
• Synonyms gene
  • C9orf3
• Synonyms gene name
  • chromosome 9 open reading frame 3
• Synonyms
  • C90RF3
  • FLJ14675
  • APO
  • AP-O
• Synonyms name
  • aminopeptidase O
• GenBank acession
  • AF043896
• Locus
  9q22.32
• Discovery year
  1999-01-28
• Entrez gene record
  84909
• Pubmed identfication
  • 15687497
• RefSeq identity
  • NM_032823
• Classification
  • M1 metallopeptidases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000020276

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