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Cetirizine dihydrochloride

  • Catalog number
    B2993-100
  • Product name
    Cetirizine dihydrochloride
  • Size
    100 mg
  • Description
    Cetirizine is a selective histamine H1 receptor antagonist with a Ki of 6 nM. It is a highly efficacious, well-tolerated, treatment for the management of Allergic Rhinitis. Cetirizine exerts anti-inflammatory effects apart from H1 antagonism. It significantly decreases the amounts of leukotriene B4 generated from neutrophil granulocytes. It inhibits aerosol histamine-induced bronchospasm in guinea pigs (ED₅₀ value of 100 μg/kg, p.o.).
  • CAS Number
    83881-52-1
  • Structure Available
    True
  • Salt Form
    True
  • Molecular Formula
    C₂₁H₂₇Cl₃N₂O₃
  • Molecular Weight
    461.81
  • Cell Permeable
    True
  • Purity
    >98.0%
  • Solubilities
    ~10 mg/ml in PBS, pH 7.2, ~12 mg/ml in DMSO, ~3 mg/ml in DMF
  • Handling
    Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
  • Tag Line
    A selective histamine H1 receptor antagonist
  • Storage Condition
    -20ºC
  • Shipping Condition
    RT
  • Shelf Life
    36 months
  • MDL Number
    MFCD00941428
  • PubChem CID
    55182
  • PubChem CID Link
    PubChem_CID_Link
  • SMILES
    C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
  • InChi
    InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
  • InChi Key
    PGLIUCLTXOYQMV-UHFFFAOYSA-N
  • Data Sheet Link
    Data_Sheet_Link
  • MSDS Available
    1
  • Gene target
    Cetirizine dihydrochloride
  • Short name
    Cetirizine dihydrochloride