Cetirizine dihydrochloride

• Catalog number
  B2993-100
• Price
  Please ask
• Size
  100 mg

• Alternative_name
  2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid,dihydrochloride; (+/-)-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)acetic acid, dihydrochloride; UCB-P 071; Zyrtec; Reactine
• Description
  Cetirizine is a selective histamine H1 receptor antagonist with a Ki of 6 nM. It is a highly efficacious, well-tolerated, treatment for the management of Allergic Rhinitis. Cetirizine exerts anti-inflammatory effects apart from H1 antagonism. It significantly decreases the amounts of leukotriene B4 generated from neutrophil granulocytes. It inhibits aerosol histamine-induced bronchospasm in guinea pigs (ED₅₀ value of 100 μg/kg, p.o.).
• CAS Number
  83881-52-1
• Structure Available
  True
• Salt Form
  True
• Molecular Formula
  C₂₁H₂₇Cl₃N₂O₃
• Molecular Weight
  461.81
• Cell Permeable
  True
• Purity
  >98.0%
• Solubilities
  ~10 mg/ml in PBS, pH 7.2, ~12 mg/ml in DMSO, ~3 mg/ml in DMF
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A selective histamine H1 receptor antagonist
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• MDL Number
  MFCD00941428
• PubChem CID
  55182
• PubChem CID Link
• SMILES
  C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
• InChi
  InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
• InChi Key
  PGLIUCLTXOYQMV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  Cetirizine   dihydrochloride  
• Short name
  Cetirizine dihydrochloride
• Alternative name
  Cetirizine dihydrochloride

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