Lapatinib,EGFR, HER2 inhibitor

Research Area s

Cell Signaling , Cancer , Apoptosis , Cancer Growth Inhibitors , Growth Factor Receptor Inhibitors
Category

Small Molecules
Product Type

Inhibitor
CAS No

231277-92-2
MolecularFormula

C29H26ClFN4O4S
Molecular Weight

581.1
Purity

≥99%
Solubility

Solubility in water is 0.007 mg/ml and in 0.1N HCl is 0.001 mg/ml at 25° C
Appearance

Yellow crystalline solid
Storage Temperature

-20°C
Shipping Temperature

Shipped Ambient
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

Lapatinib EGFR HER2 inhibitor
Gene symbol

EGFR-AS1, EGILA, EGFR, ERBB2, RHBDF1
Short name

Lapatinib EGFR, HER2 inhibitor
Alternative name

Lapatinib,epidermal growth factor receptor, HER2 suppressor
Alternative to gene target

epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217

Identity

HGNC:3236
Gene

EGFR
Long gene name

epidermal growth factor receptor
Synonyms gene
- ERBB
Synonyms gene name
- epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
Synonyms
- ERBB1
- ERRP
Synonyms name
- erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)
- erb-b2 receptor tyrosine kinase 1
Locus

7p11.2
Discovery year

1986-01-01
Entrez gene record

1956
Pubmed identfication
- 1505215
RefSeq identity
- NM_005228
Classification
- Erb-b2 receptor tyrosine kinases
VEGA ID

OTTHUMG00000023661
Locus Specific Databases
- LRG_304

Identity

HGNC:3430
Gene

ERBB2
Long gene name

erb-b2 receptor tyrosine kinase 2
Synonyms gene
- NGL
Synonyms gene name
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Synonyms
- NEU
- HER-2
- CD340
- HER2
Synonyms name
- neuro/glioblastoma derived oncogene homolog
- human epidermal growth factor receptor 2
GenBank acession
- X03363
Locus

17q12
Discovery year

2001-06-22
Entrez gene record

2064
RefSeq identity
- NM_004448
Classification
- Erb-b2 receptor tyrosine kinases
- CD molecules
- Minor histocompatibility antigens
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000179300
Locus Specific Databases
- LRG_724

Identity

HGNC:20561
Gene

RHBDF1
Long gene name

rhomboid 5 homolog 1
Synonyms gene
- C16orf8
Synonyms gene name
- chromosome 16 open reading frame 8
- rhomboid family 1 (Drosophila)
- rhomboid 5 homolog 1 (Drosophila)
Synonyms
- EGFR-RS
- FLJ2235
- Dist1
- iRhom1
GenBank acession
- BC014425
Locus

16p13.3
Discovery year

2003-04-07
Entrez gene record

64285
Pubmed identfication
- 8318735
- 15965977
RefSeq identity
- NM_022450
Classification
- Rhomboid family
VEGA ID

OTTHUMG00000060719