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Immunogen
A phospho-specific peptide corresponding to residues surrounding Tyr685 and Tyr686 of human Tyro3 (AA682-689)
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Antibody s target
Human TYRO3 (pTyr685 + pTyr686)
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Antibody s full description
Rabbit Anti-Human TYRO3 (pTyr685 + pTyr686) Polyclonal
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Antibody s category
Polyclonal Antibodies
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Antibody s other name
Brt Antibody, BYK Antibody, DTK Antibody, RSE Antibody, SKY Antibody, Tif Antibody, tyro3 Antibody, TYRO3_HUMAN Antibody, Tyrosine-protein kinase byk Antibody, Tyrosine-protein kinase DTK Antibody, Tyrosine-protein kinase receptor TYRO3 Antibody, Tyrosine-protein kinase RSE Antibody, Tyrosine-protein kinase SKY Antibody
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Verified applications
WB, AM
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Raised in
Rabbit
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Antibody s reactivity
Human
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Antibody s recommended dilutions for use
WB (1:250); optimal dilutions for assays should be determined by the user.
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Antibody s purified from
Peptide Affinity Purified
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Recommended buffer for storage
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
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Antibody s concentration
See included datasheet or contact our support service
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Antibody s specificity
Detects 96.905 kDa.
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Storage recommendations
-20°C
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Shipping recommendations
Blue Ice or 4°C
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Certificate of analysis
A 1:250 dilution of SPC-1093 was sufficient for detection of TYRO3 (pTyr685 + pTyr686) in 10 µg of mouse brain lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
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Antibody in cell
Cell membrane
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Tissue specificity
Highly expressed in the brain. Lower levels in other tissues.
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Scientific context
TYRO3 responds to TUB, TULP1, GAS6 and protein S as ligands and regulates cell survival, proliferation, immunoregulation, phagocytosis, cell migration, actin organization, spermatogenesis, platelet aggregation, clot stabilization, memory formation, circadian rhythm and synaptic plasticity. signalling transduction can occur via MAPK/ERK and Pi3K/AKT pathways. Overexpression by various cancers provide transformative ability and increased survival signals.
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Bibliography
Refer to PubMed
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Released date
29/Aug/2016
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NCBI number
NP_006284
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Gene number
7301
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Protein number
Q06418
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Antibody s datasheet
Contact our support service to receive datasheet or other technical documentation.
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Representative figure link
No Data Available
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
1.4
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Net weight g
0.1
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Stock availabilit
In Stock
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Test
StressMark antibodies supplies antibodies that are for research of human proteins.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Group
Polyclonals and antibodies
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About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
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Gene target
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Gene symbol
TYRO3
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Short name
Rabbit Anti- TYRO3 (pTyr685 + pTyr686) Polyclonal: ATTO 700
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Technique
anti-Human, Polyclonal, Rabbit, anti-, anti, antibody to, antibodies, antibodies against human proteins, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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Host
Rabbit, Rabbits
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Isotype
Immunoglobulin
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Label
ATTO 700
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Species
Human, Humans
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Alternative name
production species: rabbit Antibody toHuman TYRO3 protein tyrosine kinase (pTyr685 + pTyr686) polyclonal: ATTO 700
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Alternative technique
polyclonals, rabbit-anti, antibodies
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Alternative to gene target
TYRO3 protein tyrosine kinase, BYK and Dtk and RSE and Sky and Tif, TYRO3 and IDBG-7206 and ENSG00000092445 and 7301, transferase activity, nuclei, Tyro3 and IDBG-199993 and ENSMUSG00000027298 and 22174, TYRO3 and IDBG-646302 and ENSBTAG00000001694 and 788224
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