U-0126, MEK inhibitor

• Catalog number
  SIH-380-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  109511-58-2
• Description
  MEK inhibitor
• Molecular weight
  380,5 g/mol
• Primary research fields
  Cell Signaling
• Other name
  1,4-Diamino-2,3-dicyano-1,4-bis[2-a­minophenylthio]butadiene
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C18H16N6S2
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in DMSO (>10 mg/ml), 100% ethanol (2 mg/ml)
• Physical appearance
  White solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• PubChem number
  3006531
• Scientific context
  U-0126 is a novel, potent and selective MEK inhibitor (MEK1; IC50=72nM, MEK2; IC50=58nM). Inhibits AP-1 transcription activity. Blocks the production of inflammatory cytokines and matrix metalloproteinases. Binding of extracellular growth factors to cell surface receptors often results in activation of the mitogen-activated protein kinase (MAPK). MAPK is regulated by MAPK kinase, also called MEK. Deprivation of growth factors during cell culture or intracellular MEK inhibition leads to inhibition of proliferation and apoptotic cell death. N Blank et al. (2002) have shown that U0126, a common used MEK inhibitor and compound that itself has no intrinsic fluorescence in vitro but develops an intensive fluorescence during cell culture which can be observed in all fluorescence channels with predominance in the FL1 channel (525nm).
• Bibliography
  1. Duncia J.V., et a.l (1998) Bioorg. Med. Chem. Lett. 8(20): 2839-44. 2. Favata M.F., et al. (1998) J. Biol. Chem. 273(29): 18623-32. 3. Davies S.P., et al. (2000) Biochem. J. 351(Pt1): 95-105. 4. Namura S., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(20): 11569-74.
• Release date
  17-Jul-2013
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of U-0126 (SIH-380), a MEK inhibitor. CAS #: 109511-58-2. Molecular Formula: C18H16N6S2. Molecular Weight: 380.5 g/mol. Chemical structure of U-0126, a MEK inhibitor (SIH-380). CAS # 109511-58-2. Molecular Formula: C18H16N6S2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  U-0126   MEK   inhibitor  
• Gene symbol
  HLA-U, UTS2, CENPU
• Short name
  U-0126, MEK inhibitor
• Alternative name
  U-0126, MEK suppressor

Gene info

• Identity
  HGNC:23477
• Gene
  HLA-U
• Long gene name
  major histocompatibility complex, class I, U (pseudogene)
• Synonyms gene
  • HLA-21
• Synonyms gene name
  • HLA-21 pseudogene
• Synonyms
  • Em:AB023056.13
• GenBank acession
  • M96330
• Locus
  6p22.1
• Discovery year
  2004-01-16
• Entrez gene record
  352965
• RefSeq identity
  • NG_002398
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031245
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:12636
• Gene
  UTS2
• Long gene name
  urotensin 2
• Synonyms
  • UII
  • U-II
  • UCN2
  • PRO1068
• Synonyms name
  • prepro U-II
• GenBank acession
  • AF104118
• Locus
  1p36.23
• Discovery year
  2000-03-22
• Entrez gene record
  10911
• Pubmed identfication
  • 9861051
  • 10499587
• RefSeq identity
  • NM_006786
• Classification
  • Receptor ligands
  • Neuropeptides
• VEGA ID
  OTTHUMG00000001218

Gene info

• Identity
  HGNC:21348
• Gene
  CENPU
• Long gene name
  centromere protein U
• Synonyms gene
  • MLF1IP
• Synonyms gene name
  • MLF1 interacting protein
• Synonyms
  • CENP-U
  • KLIP1
  • CENP-50
  • PBIP1
• Synonyms name
  • polo-box-interacting protein 1
• GenBank acession
  • AK027121
  • AF516710
• Locus
  4q35.1
• Discovery year
  2003-07-17
• Entrez gene record
  79682
• Pubmed identfication
  • 15116101
  • 16622420
  • 16622419
• RefSeq identity
  • NM_024629
• Classification
  • Constitutive centromere associated network
• VEGA ID
  OTTHUMG00000160499

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