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Stock availabilitIn Stock
In Stock
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CAS number
53902-12-8
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Description
Angiogenesis inhibitor
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Molecular weight
327,33 g/mol
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Primary research fields
Cell Signaling, Neuroscience, Cancer, Cardiovascular System
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Other name
2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2- enoyl]amino}benzoic acid
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C18H17NO5
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Origin
Synthetic
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Purity pourcentage
≥95% (HPLC)
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Soluble in
Soluble in DMSO.
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Physical appearance
Off-white to yellow powder.
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302 – Harmful if swallowed. H312 – Harmful in contact with skin. H332 – Harmful if inhaled. Precautionary Phrases: P261 – Avoid breathing dust/fume/gas/mist/vapours/spray P280 – Wear protective gloves/protective clothing/eye protection/face protection. P301+ P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P304+P340 – IF INHALED: remove victim to fresh air and keep at rest in a position comfortable for breathing. P501 – Dispose of contents/container in accordance with local/regional/national/ international regulations.
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PubChem number
5282230
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Scientific context
Tranilast is an antiallergic, antifibrotic drug that inhibits collagen synthesis, when administered in a dose –dependent manner for a 48 h treatment (1). As an antifibrotic agent, studies shown an effect on the growth of metastasis of mammary carcinoma. It is associated with the inhibition of the growth factor –beta. (TGF-beta) (2).
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Bibliography
1. Yamada H., Tajima S., Nishikawa T., Murad S., and Pinnell S., (1999) The Journal of Biochemistrystry. 116(4): 892-897. 2. Chakrabarti R., Subramanian V., Abadalla J., Jothy S., Predhomme GJ. (2009) Anticancer Drugs. 20(5): 334-45.
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Release date
4-Apr-2013
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Tranilast (SIH-369), a Angiogenesis inhibitor. CAS #: 53902-12-8. Molecular Formula: C18H17NO5 . Molecular Weight: 327.33 g/mol. Chemical structure of Tranilast, a Angiogenesis inhibitor (SIH-369). CAS # 53902-12-8. Molecular Formula: C18H17NO5 .
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
