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Category
Primary Antibodies
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Long description
BAI1 is an Orphan-B GPCR with an unknown ligand. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis, and a growth suppressor of glioblastoma. Along with BAI1, there are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3, which have similar tissue specificities and structures. However, only BAI1 is transcriptionally regulated by p53. Loss of BAI1 expression has been implicated in glioblastoma.
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Antibody come from
Synthetic peptide derived from the N-terminal extracellular domain of human CERK
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Other description
Phosphate buffered saline containing 0.1% sodium azide. Immunoaffinity Purification
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Clone
Polyclonal
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Antigen antibody binding interaction
Rabbit anti Brain-Specific Angiogenesis Inhibitor 1 (BAI1) Antibody
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Antibody is raised in
Rabbit
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Antibody s reacts with
Human
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
Immunohistochemistry
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Antibody s suited for
Antibody can be used for immunohistochemistry (20 µg/ml). Optimal concentration should be evaluated by serial dilutions.
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Storage
Long term: -70ºC; Short term: +4ºC
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Relevant references
1. Lamour NF, Chalfant CE. ÔCeramide-1-phosphate: The missing link in eicosanoid biosynthesis and inflammation.Õ Mol Interv. 2005 Dec;5(6):358-67. _x000B__x000B_2.Kim JW, Inagaki Y, Mitsutake S, Maezawa N, Katsumura S, Ryu YW, Park CS, Taniguchi M, Igarashi Y. ÔSuppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1.Õ Biochim Biophys Acta. 2005 Dec 30;1738(1-3):82-90. Epub 2005 Nov 14. _x000B__x000B_3. Van Overloop H, Gijsbers S, Van Veldhoven PP. ÔFurther characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.Õ_x000B_J Lipid Res. 2006 Feb;47(2):268-83. Epub 2005 Nov 3. _x000B__x000B_4. Chalfant CE, Spiegel S. ÔSphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling.Õ J Cell Sci. 2005 Oct 15;118(Pt 20):4605-12. Review. _x000B__x000B_5. Mitsutake S, Igarashi Y. ÔCalmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium sensor.Õ J Biol Chem. 2005 Dec 9;280(49):40436-41. Epub 2005 Oct 3. _x000B__x000B_6. Wijesinghe DS, Massiello A, Subramanian P, Szulc Z, Bielawska A, Chalfant CE. ÔSubstrate specificity of human ceramide kinase.Õ_x000B_J Lipid Res. 2005 Dec;46(12):2706-16. Epub 2005 Sep 18. _x000B__x000B_7.Kim TJ, Mitsutake S, Kato M, Igarashi Y. ÔThe leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity.Õ FEBS Lett. 2005 Aug 15;579(20):4383-8.
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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About
Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
