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Stock availabilitIn Stock
In Stock
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CAS number
52809-07-1
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Description
Glutamate receptor agonist
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Molecular weight
189,13 g/mol
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Primary research fields
Neuroscience, Ion Channels, Neurotransmitter Receptors, Glutamate Receptors, AMPA Receptors
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Other name
(L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
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Product category
Small Molecules
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Product type
Agonist
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Chemical formula
C5H7N3O5
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Origin
Isolated from Quisqualis fructus
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Purity pourcentage
99.2%
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Soluble in
Soluble to 100 mM in 1eq. NaOH; 10 mM in water
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Physical appearance
Off white solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 + H312 Harmful if swallowed or in contact with skin H332 Harmful if inhaled. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ protective clothing. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P322 Specific measures (see supplemental first aid instructions on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P501 Dispose of contents/ container to an approved waste disposal plant.
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PubChem number
40539
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Scientific context
Quisqualic acid is a glutamate receptor and AMPA ionotropic receptors agonist. It is also known to sensitize neurons in hippocampus to depolarization by L-AP6.
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Bibliography
1. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7. 2. Schoepp D., & Conn P. (1993) Trends Pharmacol Sci. 13-20.
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Release date
21-May-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Quisqualic Acid (SIH-418), a Glutamate receptor agonist. CAS #: 52809-07-1. Molecular Formula: C5H7N3O5. Molecular Weight: 189.13 g/mol. Chemical structure of Quisqualic Acid, a Glutamate receptor agonist (SIH-418). CAS # 52809-07-1. Molecular Formula: C5H7N3O5.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
