P32/98, DPPIV/DPP4 inhibitor

• Catalog number
  SIH-385-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  136259-20-6
• Description
  DPPIV/DPP4 inhibitor
• Molecular weight
  260,4 g/mol
• Primary research fields
  Cell Signaling
• Other name
  3-N-[((2S,3S)-2-Amino-3-methylpentanoyl]-1,3-thiazolidine. hemi-fumarate, (2S,3S)-2-Amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one fumarate
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C9H18N2OS•0.5C4H4O4
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in water (20 mg/ml) or DMSO (25 mg/ml)
• Physical appearance
  White solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes
• PubChem number
  77519185
• Scientific context
  P32/98 (Ile-thiazolidide) is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV; DPPIV; CD26), with a Ki of 130 nM (1-3). Useful in diabetes research. Has been used in vivo (10mg/kg orally twice daily)(4-7) and in tissue culture (1-10 µM) (8).
• Bibliography
  1. Schön E., et al. (1991) Biol. Chem. Hoppe Seyler. 372(5): 305-11. 2. Pederson R.A., et al. (1998) Diabetes. 47(8): 1253-8. 3. Lankas G.R., et al. (2005) Diabetes. 54(10): 2988-94. 4. Pospisilik J.A., et al. (2002) Diabetes. 51(4): 943-50. 5. Pospisilik J.A., et al. (2002) Diabetes. 51(9): 2677-83. 6. Pospisilik J.A., et al. (2003) Diabetes. 52(3): 741-50. 7. Meyer A., et al. (1993) J. Chromatogr. B. 796(2): 401-11. 8. Girardi A.C.C., et al. (2004) Am. J. Physiol. Cell. Physiol. 287(5): C1238-45.
• Release date
  17-Jul-2013
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of P32/98 (SIH-385), a DPPIV/DPP4 inhibitor. CAS #: 136259-20-6. Molecular Formula: C9H18N2OS . 0.5 C4H4O4. Molecular Weight: 260.4 g/mol. Chemical structure of P32/98, a DPPIV/DPP4 inhibitor (SIH-385). CAS # 136259-20-6. Molecular Formula: C9H18N2OS . 0.5 C4H4O4.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  P32/98   DPPIV/DPP4   inhibitor  
• Gene symbol
  DPP4, DPP4-DT, FAP, C1QBP
• Short name
  P32/98, DPPIV/DPP4 inhibitor
• Alternative name
  P32/98, DPPIV/dipeptidyl-peptidase 4 suppressor
• Alternative to gene target
  dipeptidyl-peptidase 4, ADABP and ADCP2 and CD26 and DPPIV and TP103, DPP4 and IDBG-73658 and ENSG00000197635 and 1803, protein homodimerization activity, Cell surfaces, Dpp4 and IDBG-173968 and ENSMUSG00000035000 and 13482, DPP4 and IDBG-641297 and ENSBTAG00000015330 and

Gene info

• Identity
  HGNC:3009
• Gene
  DPP4
• Long gene name
  dipeptidyl peptidase 4
• Synonyms gene
  • CD26
  • ADCP2
• Synonyms gene name
  • dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
  • adenosine deaminase complexing protein 2
  • dipeptidyl-peptidase 4
• Synonyms
  • DPPIV
• GenBank acession
  • M74777
• Locus
  2q24.2
• Discovery year
  1990-03-05
• Entrez gene record
  1803
• Pubmed identfication
  • 8101391
• Classification
  • CD molecules
  • DASH family
• VEGA ID
  OTTHUMG00000132056

Gene info

• Identity
  HGNC:40191
• Gene
  DPP4-DT
• Long gene name
  DPP4 divergent transcript
• Locus
  2q24.2
• Discovery year
  2019-07-25
• Entrez gene record
  100131604
• RefSeq identity
  • NR_147697
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:3590
• Gene
  FAP
• Long gene name
  fibroblast activation protein alpha
• Synonyms gene name
  • fibroblast activation protein, alpha
• Synonyms
  • DPPIV
• Synonyms name
  • seprase
• GenBank acession
  • U09278
• Locus
  2q24.2
• Discovery year
  1995-03-28
• Entrez gene record
  2191
• Pubmed identfication
  • 9247085
  • 14707457
• Classification
  • DASH family
• VEGA ID
  OTTHUMG00000153890

Gene info

• Identity
  HGNC:1243
• Gene
  C1QBP
• Long gene name
  complement C1q binding protein
• Synonyms gene
  • HABP1
• Synonyms gene name
  • complement component 1, q subcomponent binding protein
• Synonyms
  • gC1Q-R
  • gC1qR
  • p32
  • SF2p32
• Synonyms name
  • C1q globular domain-binding protein
  • hyaluronan-binding protein 1
  • splicing factor SF2-associated protein
• GenBank acession
  • X75913
• Locus
  17p13.2
• Discovery year
  1995-12-11
• Entrez gene record
  708
• Pubmed identfication
  • 8567680
  • 8195709
• RefSeq identity
  • NM_001212
• VEGA ID
  OTTHUMG00000177875

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