P32/98, DPPIV/DPP4 inhibitor
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Catalog numberSIH-385-50MG
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PricePlease ask
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Size50 mg
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Stock availabilitIn StockIn Stock
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CAS number136259-20-6
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DescriptionDPPIV/DPP4 inhibitor
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Molecular weight260,4 g/mol
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Primary research fieldsCell Signaling
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Other name3-N-[((2S,3S)-2-Amino-3-methylpentanoyl]-1,3-thiazolidine. hemi-fumarate, (2S,3S)-2-Amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one fumarate
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC9H18N2OS•0.5C4H4O4
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OriginSynthetic
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Purity pourcentage>98%
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Soluble inSoluble in water (20 mg/ml) or DMSO (25 mg/ml)
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Physical appearanceWhite solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes
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PubChem number77519185
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Scientific contextP32/98 (Ile-thiazolidide) is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV; DPPIV; CD26), with a Ki of 130 nM (1-3). Useful in diabetes research. Has been used in vivo (10mg/kg orally twice daily)(4-7) and in tissue culture (1-10 µM) (8).
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Bibliography1. Schön E., et al. (1991) Biol. Chem. Hoppe Seyler. 372(5): 305-11. 2. Pederson R.A., et al. (1998) Diabetes. 47(8): 1253-8. 3. Lankas G.R., et al. (2005) Diabetes. 54(10): 2988-94. 4. Pospisilik J.A., et al. (2002) Diabetes. 51(4): 943-50. 5. Pospisilik J.A., et al. (2002) Diabetes. 51(9): 2677-83. 6. Pospisilik J.A., et al. (2003) Diabetes. 52(3): 741-50. 7. Meyer A., et al. (1993) J. Chromatogr. B. 796(2): 401-11. 8. Girardi A.C.C., et al. (2004) Am. J. Physiol. Cell. Physiol. 287(5): C1238-45.
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Release date17-Jul-2013
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of P32/98 (SIH-385), a DPPIV/DPP4 inhibitor. CAS #: 136259-20-6. Molecular Formula: C9H18N2OS . 0.5 C4H4O4. Molecular Weight: 260.4 g/mol. Chemical structure of P32/98, a DPPIV/DPP4 inhibitor (SIH-385). CAS # 136259-20-6. Molecular Formula: C9H18N2OS . 0.5 C4H4O4.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.05
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolDPP4, DPP4-DT, FAP, C1QBP
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Short nameP32/98, DPPIV/DPP4 inhibitor
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Alternative nameP32/98, DPPIV/dipeptidyl-peptidase 4 suppressor
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Alternative to gene targetdipeptidyl-peptidase 4, ADABP and ADCP2 and CD26 and DPPIV and TP103, DPP4 and IDBG-73658 and ENSG00000197635 and 1803, protein homodimerization activity, Cell surfaces, Dpp4 and IDBG-173968 and ENSMUSG00000035000 and 13482, DPP4 and IDBG-641297 and ENSBTAG00000015330 and
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Gene info
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Identity
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Gene
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Long gene namedipeptidyl peptidase 4
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Synonyms gene
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Synonyms gene name
- dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
- adenosine deaminase complexing protein 2
- dipeptidyl-peptidase 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1990-03-05
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Entrez gene record
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Pubmed identfication
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Classification
- CD molecules
- DASH family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameDPP4 divergent transcript
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Locus
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Discovery year2019-07-25
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Entrez gene record
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RefSeq identity
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Classification
- Divergent transcripts
Gene info
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Identity
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Gene
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Long gene namefibroblast activation protein alpha
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Synonyms gene name
- fibroblast activation protein, alpha
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-03-28
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Entrez gene record
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Pubmed identfication
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Classification
- DASH family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecomplement C1q binding protein
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Synonyms gene
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Synonyms gene name
- complement component 1, q subcomponent binding protein
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-12-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID