-
Stock availabilitIn Stock
In Stock
-
CAS number
396129-53-6
-
Description
ALK5 kinase inhibitor
-
Molecular weight
272,3 g/mol
-
Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
-
Other name
LY 364947, HTS 466284, ALK5 Inhibitor I, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline, HTS 466284, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor
-
Product category
Small Molecules
-
Product type
Inhibitor
-
Chemical formula
C17H12N4
-
Origin
Synthetic
-
Purity pourcentage
≥98% (HPLC)
-
Soluble in
Soluble to 100 mM in DMSO
-
Physical appearance
Yellow to brown solid
-
Storage recommendations
-20ºC
-
Shipping recommendations
Shipped Ambient
-
Safety information
Classification: Acute toxicity, Oral (Category 3), H301 Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H410 Very toxic to aquatic life with long lasting effects. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P391 Collect spillage. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
-
PubChem number
447966
-
Scientific context
LY364947 is a potent and selective inhibitor of TGF-β type-1 receptor kinase. Specifically, it inhibits TGF-β signaling and gene transcription. LY364947 is cell permeable and ATP-competitive.
-
Bibliography
1. Vogt J., Traynor R., & Sapkota G.P. (2011) Cell. Signal. 23(11): 1831–1842.
-
Release date
1-Oct-2014
-
PubMed number
Refer to PubMed
-
Tested applications
To be tested
-
Tested reactivity
To be tested
-
-
Representative figure legend
Chemical structure of LY364947 (SIH-504), a ALK5 kinase inhibitor. CAS #: 396129-53-6. Molecular Formula: C17H12N4. Molecular Weight: 272.3 g/mol. Chemical structure of LY364947, a ALK5 kinase inhibitor (SIH-504). CAS # 396129-53-6. Molecular Formula: C17H12N4.
-
Warning information
Non-hazardous
-
Country of production
Canada
-
Total weight kg
0.25
-
Net weight g
0.025
-
-
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
