LY364947
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Catalog number2646-1
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PricePlease ask
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Size1 mg
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Alternative_name4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline; HTS 466284
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DescriptionLY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC₅₀ value of 59 nM. LY364947 only weakly inhibits TGF-β RII (IC₅₀ = 400 nM), p38 MAPK (IC₅₀ = 740 nM), and mixed lineage kinase-7 (MLK-7; IC₅₀ = 1,400 nM).It inhibits TGF-β-induced cell growth (IC₅₀ = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-β-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.
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CAS Number396129-53-6
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₇H₁₂N₄
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Molecular Weight272.31
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~ 25 mg/ml)
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HandlingProtect from air and light
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Tag LineA selective TGF-β RI (ALK-5) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life48 months
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PubChem CID447966
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SMILESC1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4
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InChiInChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
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InChi KeyIBCXZJCWDGCXQT-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameLY364947
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Alternative nameLY364947
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