HC-030031, TRPA1 blocker

• Catalog number
  SIH-303-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  349085-38-7
• Description
  TRPA1 blocker
• Molecular weight
  355,39 g/mol
• Primary research fields
  Neuroscience, Ion Channels, Transient Receptor Potential Channels
• Other name
  2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C18H21N5O3
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble to 100 mM in DMSO
• Physical appearance
  White solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H301 Precautionary Phrases: P301 + P310
• PubChem number
  1150897
• Scientific context
  Selective TRPA1 channel blocker that antagonizes AITC-and formalin-evoked calcium influx. Doe not block currents mediated by TRPV1, V3, V4, hERG or Nav1.2 channels (1-2).
• Bibliography
  1. McNamara C.R., et al. (2007) Proc Natl Acad Sci USA. 104(33): 13525-13530. 2. Taylor-Clark T.E., et al. (2008) Mol Pharmacol. 73(2): 274-281.
• Release date
  8-Apr-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of HC-030031 (SIH-303), a TRPA1 blocker. CAS #: 349085-38-7. Molecular Formula: C18H21N5O3. Molecular Weight: 355.39 g/mol. Chemical structure of HC-030031, a TRPA1 blocker (SIH-303). CAS # 349085-38-7. Molecular Formula: C18H21N5O3.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products

• Gene target
  HC-030031   TRPA1   blocker  
• Gene symbol
  TRPA1, CLTC, SRRD, SERPIND1
• Short name
  HC-030031, TRPA1 blocker
• Alternative name
  HC-030031, TRPA1 blocker

Gene info

• Identity
  HGNC:497
• Gene
  TRPA1
• Long gene name
  transient receptor potential cation channel subfamily A member 1
• Synonyms gene
  • ANKTM1
• Synonyms gene name
  • ankyrin-like with transmembrane domains 1
  • transient receptor potential cation channel, subfamily A, member 1
• GenBank acession
  • Y10601
• Locus
  8q21.11
• Discovery year
  1999-01-15
• Entrez gene record
  8989
• Pubmed identfication
  • 16382100
• RefSeq identity
  • NM_007332
• Classification
  • Ankyrin repeat domain containing
  • Transient receptor potential cation channels
• VEGA ID
  OTTHUMG00000164516

Gene info

• Identity
  HGNC:2092
• Gene
  CLTC
• Long gene name
  clathrin heavy chain
• Synonyms gene
  • CLTCL2
• Synonyms gene name
  • clathrin, heavy polypeptide (Hc)
  • clathrin, heavy chain
  • clathrin, heavy polypeptide-like 2
  • clathrin, heavy chain (Hc)
• Synonyms
  • Hc
• GenBank acession
  • X55878
• Locus
  17q23.1
• Discovery year
  1990-10-16
• Entrez gene record
  1213
• Pubmed identfication
  • 1765375
  • 7584026
• RefSeq identity
  • NM_004859
• Classification
  • Clathrin subunits
• VEGA ID
  OTTHUMG00000134279

Gene info

• Identity
  HGNC:33910
• Gene
  SRRD
• Long gene name
  SRR1 domain containing
• Synonyms
  • HC/HCC
  • SRR1L
• Synonyms name
  • hepatocellular carcinoma complicating hemochromatosis
• GenBank acession
  • BC066962
• Locus
  22q12.1
• Discovery year
  2007-12-05
• Entrez gene record
  402055
• RefSeq identity
  • NM_001013694
• VEGA ID
  OTTHUMG00000150885

Gene info

• Identity
  HGNC:4838
• Gene
  SERPIND1
• Long gene name
  serpin family D member 1
• Synonyms gene
  • HCF2
• Synonyms gene name
  • serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
  • serpin peptidase inhibitor, clade D (heparin cofactor), member 1
• Synonyms
  • HC-II
  • HLS2
  • HC2
  • D22S673
• Synonyms name
  • heparin cofactor II
  • heparin cofactor 2
• GenBank acession
  • M12849
• Locus
  22q11.21
• Discovery year
  1988-05-31
• Entrez gene record
  3053
• Pubmed identfication
  • 1671335
  • 24172014
• RefSeq identity
  • NM_000185
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000150755
• Locus Specific Databases
  • LRG_594

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