Erlotinib Hydrochloride, EGFR Kinase inhibitor
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Catalog number
SIH-444-10MG
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Price
Please ask
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Size
10 mg
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Stock availabilitIn Stock
In Stock
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CAS number
183319-69-9
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Description
EGFR Kinase inhibitor
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Molecular weight
429,9 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C22H24ClN3O4
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Origin
Synthetic
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Purity pourcentage
≥99%
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Soluble in
Soluble in DMSO at 18 mg/ml with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
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Physical appearance
Solid powder
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
176871
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Scientific context
Erlotinib Hydrochloride inhibits the human epidermal growth factor receptor (HER-1/EGFR) tyrosine kinase.
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Bibliography
1. Ali S., et al. (2008) Mol. Cancer Ther. 7(6): 1708–1719.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Erlotinib Hydrochloride (SIH-444), a EGFR Kinase inhibitor. CAS #: 183319-69-9. Molecular Formula: C22H24ClN3O4. Molecular Weight: 429.9 g/mol. Chemical structure of Erlotinib Hydrochloride, a EGFR Kinase inhibitor (SIH-444). CAS # 183319-69-9. Molecular Formula: C22H24ClN3O4.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
EGFR-AS1, EGILA, EGFR, RHBDF1
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Short name
Erlotinib Hydrochloride, EGFR Kinase inhibitor
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Alternative name
Erlotinib Hydrochloride, epidermal growth factor receptor phosphorylation catalyst suppressor
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Alternative to gene target
epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217
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Gene info
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Identity
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Gene
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Long gene name
EGFR antisense RNA 1
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Locus
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Discovery year
2012-11-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
EGFR interacting lncRNA
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Synonyms
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Locus
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Discovery year
2019-09-27
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Pubmed identfication
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Classification
- Long non-coding RNAs with non-systematic symbols
Gene info
Gene info
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Identity
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Gene
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Long gene name
rhomboid 5 homolog 1
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Synonyms gene
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Synonyms gene name
- chromosome 16 open reading frame 8
- rhomboid family 1 (Drosophila)
- rhomboid 5 homolog 1 (Drosophila)
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Synonyms
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GenBank acession
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Locus
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Discovery year
2003-04-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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