Ebselen, Protein Kinase C inhibitor
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Catalog number
SIH-204-50MG
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Price
Please ask
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Size
50 mg
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Stock availabilitIn Stock
In Stock
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CAS number
60940-34-3
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Description
Protein Kinase C inhibitor
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Molecular weight
274,18 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
2-Phenyl-1,2-benzoselenazol-3(2H)-one
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C13H9NOSe
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Origin
Synthetic
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Purity pourcentage
>99%
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Soluble in
Soluble in DMSO and 100% ethanol
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Physical appearance
Off-white Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful: May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: 23/25-33-50/53 Hazard Phrases: H301-H331-H373-H410 Precautionary Phrases: P261-P273-P301 + P310-P311-P501
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PubChem number
3194
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Scientific context
Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite (1). It is being investigated as a possible treatment for reperfusion injury and stroke (2, 3), as well as tinnitus (4). Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.
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Bibliography
1. Schewe T. (1995) Gen Pharmacol. 26(6): 1153-1169. 2. Parnham M., Seis H. (2000) Expert Opin Investig Drugs. 9(3): 607-619. 3. Yamaguchi T., et al. (1998) Stroke. 29(1): 12-17. 4. Kil J., Pierce C., Tran H., Gu R., Lynch E.D. (2007) Hearing Research. 226(1-2): 44-51.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Ebselen (SIH-204), a Glutathione peroxidase mimic. CAS #: 60940-34-3. Molecular Formula: C13H9NOSe. Molecular Weight: 274.18 g/mol. Chemical structure of Ebselen, a Glutathione peroxidase mimic (SIH-204). CAS # 60940-34-3. Molecular Formula: C13H9NOSe.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.05
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short name
Ebselen, Protein Kinase C inhibitor
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Alternative name
Ebselen, Protein phosphorylation catalyst C suppressor
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