JAK3 Inhibitor

CAS number

211555-04-3
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Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

JAK3 Inhibitor
Gene symbol

JAK3
Short name

JAK3 Inhibitor
Alternative name

Janus kinase 3 suppressor
Alternative to gene target

Janus kinase 3, JAK-3 and JAK3_HUMAN and JAKL and L-JAK and LJAK, JAK3 and IDBG-37201 and ENSG00000105639 and 3718, transferase activity, Plasma membranes, Jak3 and IDBG-166648 and ENSMUSG00000031805 and 16453, BT.44422 and IDBG-641863 and ENSBTAG00000020904 and 538276

Identity

HGNC:6193
Gene

JAK3
Long gene name

Janus kinase 3
Synonyms
- L-JAK
- JAKL
- LJAK
- JAK3_HUMAN
- JAK-3
Synonyms name
- tyrosine-protein kinase JAK3
- leukocyte Janus kinase
GenBank acession
- U31601
Locus

19p13.11
Discovery year

1994-12-19
Entrez gene record

3718
Pubmed identfication
- 8921370
- 9226382
RefSeq identity
- NM_000215
Classification
- Jak family tyrosine kinases
VEGA ID

OTTHUMG00000165648
Locus Specific Databases
- JAK3base: Mutation registry for autosomal recessive severe combined JAK3 deficiency
- LRG_77