AG490,JAK-2 kinase inhibitor

Research Area s

Cell Signaling , Cancer , Apoptosis , Cancer Growth Inhibitors , Tyrosine Kinase Inhibitors
Category

Small Molecules
Product Type

Inhibitor
CAS No

133550-30-8
MolecularFormula

C17H14N2O3
Molecular Weight

294.3
Purity

≥98% (TLC)
Solubility

Soluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml)
Appearance

Tan solid
Storage Temperature

-20°C
Shipping Temperature

Shipped Ambient
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

AG490 JAK-2 kinase inhibitor
Gene symbol

JAK2, JAK3, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2, RNU6-2, KRTAP13-2
Short name

AG490 JAK-2 kinase inhibitor
Alternative name

AG490,JAK-2 phosphorylation catalyst suppressor

Identity

HGNC:6192
Gene

JAK2
Long gene name

Janus kinase 2
Synonyms
- JTK10
Locus

9p24.1
Discovery year

1992-04-16
Entrez gene record

3717
Pubmed identfication
- 1848670
Classification
- FERM domain containing
- Jak family tyrosine kinases
- SH2 domain containing
VEGA ID

OTTHUMG00000019490
Locus Specific Databases
- LRG_612

Identity

HGNC:6193
Gene

JAK3
Long gene name

Janus kinase 3
Synonyms
- L-JAK
- JAKL
- LJAK
- JAK3_HUMAN
- JAK-3
Synonyms name
- tyrosine-protein kinase JAK3
- leukocyte Janus kinase
GenBank acession
- U31601
Locus

19p13.11
Discovery year

1994-12-19
Entrez gene record

3718
Pubmed identfication
- 8921370
- 9226382
RefSeq identity
- NM_000215
Classification
- Jak family tyrosine kinases
VEGA ID

OTTHUMG00000165648
Locus Specific Databases
- JAK3base: Mutation registry for autosomal recessive severe combined JAK3 deficiency
- LRG_77