Oncostatin M Recombinant Protein
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Catalog number
40-584
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Price
Please ask
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Size
0.002 mg, 0.01 mg
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About recombinant protein
Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant rat Oncostatin M is a 24.4 kDa protein, containing 215 amino acid residues.
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Other name of the recombinant
Oncostatin-M, OSM
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Recombinant in
E. coli
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SEQUENCE
MKRGCSSSSP KLLSQLKSQA NITGNTASLL EPYILHQNLN TLTLRAACTE HPVAFPSEDM LRQLSKPDFL STVHATLGRV WHQLGAFRQQ FPKIQDFPEL ERARQNIQGI RNNVYCMARL LHPPLEIPEP TQADSGTSRP TTTAPGIFQI KIDSCRFLWG YHRFMGSVGR VFEEWGDGSR RSRRHSPLWA WLKGDHRIRP SRSSQSAMLR SLVPR
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Activity
Assay 1: Biological activity was determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 is 3.0-5.0 μg/mL.Assay 2: Biological activity was determined by its ability to inhibit Alkaline phosphatase activity of differentiated MC3T3 E1 cells. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
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Keep at
The lyophilized Oncostatin M recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Oncostatin M stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Oncostatin M recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Rec PROTEIN GI
55741439
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Accession nr
NP_001006962.1
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Pureity
Greater than 98% by SDS-PAGE gel and HPLC analyses.
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About
This product is for research use only.
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Protein s origin
Rat
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Vial
Lyophilized
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NCBI ID
289747
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Gene name
oncostatin M
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Source
Rattus norvegicus
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Uniprot
Q65Z15
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
Osm
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Short name
Oncostatin M Recombinant Protein
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative name
Oncostatin M Rec. Protein
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Alternative technique
rec
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Gene info
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Identity
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Gene
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Long gene name
oncostatin M
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Synonyms
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GenBank acession
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Locus
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Discovery year
1992-07-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukin 6 type cytokine family
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VEGA ID
Gene info
Gene info
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Identity
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Gene
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Long gene name
CCM2 scaffold protein
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Synonyms gene
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Synonyms gene name
- chromosome 7 open reading frame 22
- cerebral cavernous malformation 2
- CCM2 scaffolding protein
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2003-07-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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