Oncostatin M Recombinant Protein

• Catalog number
  40-283
• Price
  Please ask
• Size
  0.002 mg, 0.01 mg

• About recombinant protein
  Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant human Oncostatin M is a 26.0 kDa protein, containing 227 amino acid residues.
• Other name of the recombinant
  Oncostatin-M, OSM
• Recombinant in
  E. coli
• SEQUENCE
  MAAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSE ETLRGLGRRG FLQTLNATLG CVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMA QLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRF LHGYHRFMHS VGRVFSKWGE SPNRSRRHSP HQALRKGVRR TRPSRKGKRL MTRGQLPR
• Activity
  The ED50 was determined by the dose - dependent stimulation of the proliferation of human TF - 1 cells is ≤ 2 ng/mL, corresponding to a specific activity of ≥ 5 x 105 units/mg.
• Keep at
  The lyophilized Oncostatin M recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Oncostatin M is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Oncostatin M recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  10092621
• Accession nr
  NP_065391.1
• Pureity
  Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  5008
• Gene name
  oncostatin M
• Source
  Homo sapiens
• Uniprot
  P13725
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Oncostatin   Protein  
• Gene symbol
  OSM
• Short name
  Oncostatin M Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  Oncostatin M Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:8506
• Gene
  OSM
• Long gene name
  oncostatin M
• Synonyms
  • MGC20461
• GenBank acession
  • AF129855
• Locus
  22q12.2
• Discovery year
  1992-07-09
• Entrez gene record
  5008
• Pubmed identfication
  • 1717982
• RefSeq identity
  • NM_020530
• Classification
  • Interleukin 6 type cytokine family
• VEGA ID
  OTTHUMG00000150913

Gene info

• Identity
  HGNC:21708
• Gene
  CCM2
• Long gene name
  CCM2 scaffold protein
• Synonyms gene
  • C7orf22
• Synonyms gene name
  • chromosome 7 open reading frame 22
  • cerebral cavernous malformation 2
  • CCM2 scaffolding protein
• Synonyms
  • MGC4607
  • OSM
• Synonyms name
  • malcavernin
  • osmosensing scaffold for MEKK3
• GenBank acession
  • BC004903
• Locus
  7p13
• Discovery year
  2003-07-14
• Entrez gene record
  83605
• Pubmed identfication
  • 9811928
• RefSeq identity
  • NM_031443
• Classification
  • CCM adhesion complex
• VEGA ID
  OTTHUMG00000129246
• Locus Specific Databases
  • LRG_664

Gene info

• Identity
  HGNC:30391
• Gene
  IFT172
• Long gene name
  intraflagellar transport 172
• Synonyms gene name
  • intraflagellar transport 172 homolog (Chlamydomonas)
• Synonyms
  • SLB
  • wim
  • osm-1
  • NPHP17
  • BBS20
• Synonyms name
  • wimple homolog
• GenBank acession
  • AB033005
• Locus
  2p23.3
• Discovery year
  2005-11-02
• Entrez gene record
  26160
• Pubmed identfication
  • 10788441
  • 10574461
  • 24140113
  • 26763875
• RefSeq identity
  • NM_015662
• Classification
  • WD repeat domain containing
  • IFT-B2 complex
• VEGA ID
  OTTHUMG00000128425

Gene info

• Identity
  HGNC:19167
• Gene
  KIF17
• Long gene name
  kinesin family member 17
• Synonyms
  • KIAA1405
  • KIF3X
  • KIF17B
  • OSM-3
  • KLP-2
• Synonyms name
  • kinesin-like protein KIF17
  • KIF3-related motor protein
  • KIF17 variant protein
• GenBank acession
  • AB037826
• Locus
  1p36.12
• Discovery year
  2002-08-29
• Entrez gene record
  57576
• Pubmed identfication
  • 10846156
• RefSeq identity
  • NM_020816
• Classification
  • Kinesins
• VEGA ID
  OTTHUMG00000002863

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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