Integrin alpha 4 Recombinant Protein

• Catalog number
  95-110
• Price
  Please ask
• Size
  0.05 mg

• About recombinant protein
  The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains (reviewed in 1). Alpha 4 (4) chain associates with either beta 1 (1) or beta 77) chain. It has been demonstrated that the putative ligand-binding sites of both integrin 41 and 47 is located on the 4 chain. These ligands included Madcam, VCAM, and fibronectin (2-4). Madcam is known as the principal ligand for integrin a4b7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin 47, the gut mucosal homing receptor for peripheral T cells (5). This recombinant protein fragment includes the ligand and monoclonal antibody binding domains; this binding has been tested and verified in ELISA assays. This recombinant protein is recognized PSI antibodies Integrin 4 (IN1) (PSI 4827) and Integrin 4 (IN2) (PSI 4837), but not Integrin 4 (CT) (PSI 4783).
• Other name of the recombinant
  Integrin alpha 4 Antibody: IA4, CD49D, Integrin alpha-4, CD49 antigen-like family member D
• Recombinant in
  E. coli
• His tag on the recombinant protein
  Fusion Partner: N-terminal His-tag
• SEQUENCE
  aa 131 - 275
• Activity
  not available
• Use of recmbinant
  This recombinant protein can be used for WB, ELISA, MS and neutralization assays. For research use only.
• Protein is used in
  E, WB, MS
• Suspention medium
  50mM Tris pH7.5, 150mM NaCl, 5 mM MgCl2
• Keep at
  Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  67191027
• Accession nr
  NP_000876
• KDa of reombinant
  17 kDa (Calculated)
• Pureity
  ~95%
• About
  Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
• Vial
  Liquid
• NCBI ID
  3676
• Gene name
  integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
• Source
  Homo sapiens
• Uniprot
  P13612
• Pictures of recombinant
• Rec pdf
• Description
  The Integrin alpha 4 Recombinant Protein is a α- or alpha protein sometimes glycoprotein present in blood.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Integrin   alpha   Protein  
• Gene symbol
  ITGA4
• Short name
  Integrin alpha 4 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  Integrin a 4 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:6140
• Gene
  ITGA4
• Long gene name
  integrin subunit alpha 4
• Synonyms gene
  • CD49D
• Synonyms gene name
  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
• Synonyms
  • CD49d
• Synonyms name
  • antigen CD49D
  • alpha 4 subunit of VLA-4 receptor
• Locus
  2q31.3
• Discovery year
  1991-08-06
• Entrez gene record
  3676
• Pubmed identfication
  • 1537388
• Classification
  • CD molecules
  • Integrin alpha subunits
• VEGA ID
  OTTHUMG00000154212

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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