anti-NMDA NR2B (phospho Tyr1472) Antibody

• Catalog number
  XPS-1019
• Price
  Please ask
• Size
  0.1 mL

• Gene info
  The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity.
• Gene names
  GluN2B, N-methyl D-aspartate receptor subtype 2B, GluN2B
• Antibodie s label
  unlabelled serum
• Purity
  Affinity Purified
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Spicific to
  NMDA antibody is specific for ~180 kD NMDAR NR2B phosphorylated at Tyr1472.
• Antigen
  NMDA NR2B (Tyr1472) polyclonal antibody was made against a synthetic phosphopeptide corresponding to amino acids residues surrounding the phosphorylated Tyr1472 of rat NMDA NR2B.
• Immuno application
  Western Blot
• Antibody advice
  The labeling of the NR2B protein in Western blots of rat brain is blocked by the phosphopeptide but not by the dephosphopeptide. The antibody also labels bands at 65k and 115k. Applications include Dot Blots (DB) and Western Blots (WB). Human, mouse, and rat have 100% amino acid sequence identity with the antigen used to raise the antibody. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
• Suspention pH azide
  100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
• Keep at
  For long term storage –80 grades C is recommended, but shorter term storage at –20 grades C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
• Works with
  Human, Mouse, Rat
• Omim nr
  548372
• Ncbi nr
  Q00960
• KDa
  180
• Vial with antibody
  in solution
• NCBI GENE nr
  24410
• GENE symbol
  Grin2b
• Antigene name
  glutamate receptor, ionotropic, N-methyl D-aspartate 2B
• Source
  Rattus norvegicus
• Protein nr
  Q00960
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  NMDA   NR2B   phospho   Tyr1472  
• Short name
  anti-NMDA NR2B (phospho Tyr1472) Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toNMDA NR2B (phosphorilated Tyr1472) (antibody to-)
• Alternative technique
  antibodies

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products