anti-FRAP1 (phospho Ser2448) Antibody

• Catalog number
  49-374
• Price
  Please ask
• Size
  0.05 mg

• Gene info
  Mammalian target of rapamycin (mTOR) is a serine and threonine protein kinase that regulates numerous cellular functions, in particular, the initiation of protein translation. Rapamycin is a natural product macrolide that induces G1 growth arrest in yeast, Drosophila, and mammalian cells. mTOR has a long list of synonyms including FK506 binding protein12 - rapamycin associated protein 1, FK506 binding protein12 - rapamycin associated protein 2, FRAP1, FRAP2, RAFT1, RAPT1 and/or FKBP12-rapamycin associated protein (FRAP). mTOR is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, mTOR is a 245-kD protein referred to as RAFT1 with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of mTOR to FKBP12-rapamycin correlates with the ability of these ligands to inhibit cell cycle progression.
• Gene names
  MTOR, FRAP1, FRAP2, FRAP, Mammalian target of rapamycin, RAFT1, Rapamycin and FKBP12 target 1, RAPT1, Rapamycin target protein 1
• Antibodie s label
  unlabelled serum
• Purity
  Immunoaffinity Chromatography
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Spicific to
  pSer2448
• Antigen
  FRAP1 antibody was made against phospho amino acids 2440 - 2457 of FRAP1 (Human).
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry
• Antibody advice
  FRAP1 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 2.5 ug/mL.
• Suspention pH azide
  0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
• Keep at
  Store FRAP1 antibody at -20 grades C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20 grades C or below. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Human
• Omim nr
  1169735
• Ncbi nr
  P42345
• Vial with antibody
  in solution
• NCBI GENE nr
  2475
• GENE symbol
  MTOR
• Antigene name
  mechanistic target of rapamycin (serine/threonine kinase)
• Source
  Homo sapiens
• Protein nr
  P42345
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FRAP1   phospho   Ser2448  
• Gene symbol
  MTOR
• Short name
  anti-FRAP1 (phospho Ser2448) Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toFRAP1 (phosphorilated Ser2448) (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3942
• Gene
  MTOR
• Long gene name
  mechanistic target of rapamycin kinase
• Synonyms gene
  • FRAP
  • FRAP2
  • FRAP1
• Synonyms gene name
  • FK506 binding protein 12-rapamycin associated protein 1
  • mechanistic target of rapamycin (serine/threonine kinase)
  • mechanistic target of rapamycin
• Synonyms
  • RAFT1
  • RAPT1
  • FLJ44809
• Synonyms name
  • FK506 binding protein 12-rapamycin associated protein 2
  • rapamycin target protein
  • FKBP12-rapamycin complex-associated protein 1
  • FKBP-rapamycin associated protein
  • rapamycin associated protein FRAP2
  • dJ576K7.1 (FK506 binding protein 12-rapamycin associated protein 1)
  • rapamycin and FKBP12 target 1
  • mammalian target of rapamycin
• GenBank acession
  • L34075
• Locus
  1p36.22
• Discovery year
  1995-07-18
• Entrez gene record
  2475
• Pubmed identfication
  • 8008069
  • 8660990
• RefSeq identity
  • NM_004958
• Classification
  • MTOR complex 1
  • MTOR complex 2
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000002001
• Locus Specific Databases
  • LRG_734

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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