anti-FANCA Antibody

• Catalog number
  49-573
• Price
  Please ask
• Size
  0.05 mg

• Gene info
  FANCA (also called Protein FACA or Fanconi anemia group A protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCA may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Variant 1 (isoform a) encodes the longest transcript. Variant 2 (isoform b) contains an alternate exon, which results in an early stop codon, compared to variant 1. Isoform b has a shorter C-terminus when compared to isoform a. Mutations in this gene are the most common cause of Fanconi anemia.
• Gene names
  FANCA, FA1, FACA, FA-H, Fanconi anemia group A protein, Fanconi anemia, type 1, FA, Protein FACA, FAA, FANCH
• Antibodie s label
  unlabelled serum
• Purity
  Immunoaffinity Chromatography
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  FANCA antibody was made against amino acids 995-1009 of FANCA (Human).
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry
• Antibody advice
  FANCA antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 20 ug/mL.
• Suspention pH azide
  0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
• Keep at
  Store FANCA antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Chimpanzee, Human
• Omim nr
  147744560
• Ncbi nr
  O15360
• Vial with antibody
  in solution
• NCBI GENE nr
  2175
• GENE symbol
  FANCA
• Antigene name
  Fanconi anemia, complementation group A
• Source
  Homo sapiens
• Protein nr
  O15360
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FANCA  
• Gene symbol
  FANCA
• Short name
  anti-FANCA Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toFANCA (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  Fanconi anemia, complementation group A, FA and FA-H and FA1 and FAA and FACA and FAH and FANCH, FANCA and IDBG-48213 and ENSG00000187741 and 2175, protein binding, nuclei, Fanca and IDBG-198733 and ENSMUSG00000032815 and 14087, FANCA and IDBG-630970 and ENSBTAG00000001906 and

Gene info

• Identity
  HGNC:3582
• Gene
  FANCA
• Long gene name
  FA complementation group A
• Synonyms gene
  • FACA
  • FANCH
• Synonyms gene name
  • Fanconi anemia complementation group A
• Synonyms
  • FAA
  • FA-H
  • FAH
• GenBank acession
  • Z83067
• Locus
  16q24.3
• Discovery year
  1995-12-22
• Entrez gene record
  2175
• Pubmed identfication
  • 7581462
  • 9382107
• Classification
  • FA complementation groups
  • FA core complex
• VEGA ID
  OTTHUMG00000173049
• Locus Specific Databases
  • Fanconi Anaemia Mutation Database
  • Global Variome shared LOVD
  • LRG_495

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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