anti-Desmin Antibody [10H7D2]

• Catalog number
  32-145
• Price
  Please ask
• Size
  0.1 mg

• Gene info
  Desmin (DES), with 470-amino acid protein (about 52 kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.
• Gene names
  CSM1, CSM2, LGMD2R
• Antibodie s label
  unlabelled serum
• Ab raised in
  Mouse
• Type
  Monoclonal
• Monoclonal
  10H7D2
• Immunoglobulin
  IgG1
• Antigen
  Ni-NTA purified truncated recombinant Desmin expressed in E. Coli strain BL21 (DE3).
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry
• Antibody advice
  Western Blot:1:1,000 - 1:2,000 IHC(P):1:1,000 - 1:2,000IHC(F):1:1,000 - 1:2,000ELISA:Propose dilution 1:10,000.Determining optimal working dilutions by titration test.
• Suspention pH azide
  Purified antibody in PBS containing 0.03% sodium azide
• Keep at
  Desmin monoclonal antibody can be stored at -20 grades C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  6686280
• Ncbi nr
  P17661
• NCBI GENE nr
  1674
• GENE symbol
  DES
• Antigene name
  desmin
• Source
  Homo sapiens
• Protein nr
  P17661
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Gene
  Desmins or DES proteins detect by anti-desmin antibodies and DES ELISA kits. DSM1 and DSM2 play an important role in Desminopathy. Desmin regulated Myofibrilate Myopathy is a protein filament mutation of muscle proteins.
• French translation
  anticorps

• Gene target
  Desmin   [10H7D2]  
• Short name
  anti-Desmin Antibody [10H7D2]
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toDesmin (antibody to-) [10H7D2]
• Alternative technique
  antibodies

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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