anti-Caspase-8 Antibody

• Catalog number
  3473
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  Caspase-8 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.
• Gene names
  Caspase-8 Antibody: CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8, Caspase-8, Apoptotic cysteine protease, CASP-8
• Antibodie s label
  unlabelled serum
• Purity
  Caspase-8 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.
• Antigen
  Caspase-8 antibody was made against a 16 amino acid synthetic peptide from near the carboxy terminus of human Caspase-8 isoform A.
• Immuno application
  ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
• Antibody advice
  Caspase-8 antibody can be used for the detection of caspase-8 by Western blot at 0.5 to 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 2 ug/mL. For immunofluorescence start at 20 ug/mL.
• Suspention pH azide
  Caspase-8 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  Caspase-8 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  15718704
• Ncbi nr
  NP_001219
• KDa
  55 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  841
• GENE symbol
  CASP8
• Antigene name
  caspase 8, apoptosis-related cysteine peptidase
• Source
  Homo sapiens
• Protein nr
  Q14790
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Caspase-8  
• Gene symbol
  CASP8, CARD8, CASP8AP2
• Short name
  anti-Caspase-8 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toCasp-8 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1509
• Gene
  CASP8
• Long gene name
  caspase 8
• Synonyms gene name
  • caspase 8, apoptosis-related cysteine protease
  • caspase 8, apoptosis-related cysteine peptidase
• Synonyms
  • MCH5
  • MACH
  • FLICE
  • Casp-8
• GenBank acession
  • U60520
• Locus
  2q33.1
• Discovery year
  1996-11-11
• Entrez gene record
  841
• Pubmed identfication
  • 8681376
  • 8681377
• RefSeq identity
  • NM_001228
• Classification
  • Caspases
  • Death effector domain containing
  • Death inducing signaling complex
  • Ripoptosome
• VEGA ID
  OTTHUMG00000132821
• Locus Specific Databases
  • CASP8base: Mutation registry for Caspase 8 deficiency
  • LRG_34

Gene info

• Identity
  HGNC:17057
• Gene
  CARD8
• Long gene name
  caspase recruitment domain family member 8
• Synonyms gene name
  • caspase recruitment domain family, member 8
• Synonyms
  • TUCAN
  • KIAA0955
  • CARDINAL
  • NDPP
  • Dakar
• GenBank acession
  • AB023172
• Locus
  19q13.33
• Discovery year
  2003-12-03
• Entrez gene record
  22900
• Pubmed identfication
  • 10231032
  • 11408476
• RefSeq identity
  • NM_014959
• Classification
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000165047

Gene info

• Identity
  HGNC:1510
• Gene
  CASP8AP2
• Long gene name
  caspase 8 associated protein 2
• Synonyms gene name
  • CASP8 associated protein 2
• Synonyms
  • FLASH
  • CED-4
  • RIP25
  • FLJ11208
  • KIAA1315
• Synonyms name
  • FLICE-associated huge protein
• GenBank acession
  • AB037736
• Locus
  6q15
• Discovery year
  1999-12-10
• Entrez gene record
  9994
• Pubmed identfication
  • 10235259
  • 17245429
  • 17003126
• RefSeq identity
  • NM_001137667
• VEGA ID
  OTTHUMG00000015212

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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