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Gene info
Caspase-5 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18. Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1β. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma.
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Gene names
Caspase-5 Antibody: ICH-3, ICEREL-III, ICE(rel)III, ICH3, Caspase-5, Protease ICH-3, CASP-5
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Antibodie s label
unlabelled serum
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Purity
Caspase-5 Antibody is affinity chromatography purified via peptide column.
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Ab raised in
Rabbit
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Type
Polyclonal
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Immunoglobulin
IgG
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Spicific to
Depending on cell lines or tissues used, other cleavage products may be observed.
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Antigen
Caspase-5 antibody was made against a 14 amino acid synthetic peptide from the center of human Caspase-5.
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Immuno application
ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
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Antibody advice
Casp-5 antibody can be used for the detection of caspase-5 by Western blot at 0.5 - 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 2 ug/mL. For immunofluorescence start at 2 ug/mL.
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Suspention pH azide
Caspase-5 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep at
Caspase-5 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works with
Human
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Omim nr
212276423
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Ncbi nr
P51878
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
838
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GENE symbol
CASP5
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Antigene name
caspase 5, apoptosis-related cysteine peptidase
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Source
Homo sapiens
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Protein nr
P51878
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
