anti-ATR Antibody

• Catalog number
  3117
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  ATR Antibody: The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
• Gene names
  ATR Antibody: ATR, GAPO, TEM8, ATR, Anthrax toxin receptor 1, Tumor endothelial marker 8
• Antibodie s label
  unlabelled serum
• Purity
  ATR Antibody is Ion exchange chromatography purified.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  Will recognize all three isoforms.
• Antigen
  ATR antibody was made against a peptide corresponding to 13 amino acids near the center of human ATR.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
• Antibody advice
  ATR antibody can be used for detection of ATR by Western blot at 0.5 to 2 ug/mL. It will recognize all three isoforms. Antibody can also be used for immunohistochemistry starting at 2 ug/mL. For immunofluorescence start at 10 ug/mL.
• Suspention pH azide
  ATR Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  ATR antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  16933551
• Ncbi nr
  NP_444262
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  84168
• GENE symbol
  ANTXR1
• Antigene name
  anthrax toxin receptor 1
• Source
  Homo sapiens
• Protein nr
  Q9H6X2
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ATR  
• Gene symbol
  ANTXR1, SERPINA2, ATR
• Short name
  anti-ATR Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toATR (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  ataxia telangiectasia and Rad3 related, FCTCS and FRP1 and MEC1 and SCKL and SCKL1, ATR and IDBG-59521 and ENSG00000175054 and 545, transferase activity, nuclei, Atr and IDBG-191646 and ENSMUSG00000032409 and 245000, ATR and IDBG-638174 and ENSBTAG00000011529 and 504869

Gene info

• Identity
  HGNC:21014
• Gene
  ANTXR1
• Long gene name
  ANTXR cell adhesion molecule 1
• Synonyms gene name
  • anthrax toxin receptor 1
• Synonyms
  • TEM8
  • FLJ21776
  • FLJ10601
  • ATR
• Synonyms name
  • anthrax toxin receptor
  • tumor endothelial marker 8 precursor
• GenBank acession
  • AF421380
• Locus
  2p13.3
• Discovery year
  2003-08-27
• Entrez gene record
  84168
• Pubmed identfication
  • 10947988
  • 11559528
• RefSeq identity
  • NM_032208
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000129575

Gene info

• Identity
  HGNC:8985
• Gene
  SERPINA2
• Long gene name
  serpin family A member 2 (gene/pseudogene)
• Synonyms gene
  • PIL
  • SERPINA2P
• Synonyms gene name
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2, pseudogene
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)
• Synonyms
  • ATR
  • ARGS
• Synonyms name
  • protease inhibitor 1 (alpha-1-antitrypsin)-like
  • alpha-1 antitrypsin-related protein
• GenBank acession
  • JX680599
• Locus
  14q32.13
• Discovery year
  2001-06-22
• Entrez gene record
  390502
• Pubmed identfication
  • 15014966
  • 23826168
  • 24172014
• RefSeq identity
  • NM_006220
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000171347

Gene info

• Identity
  HGNC:882
• Gene
  ATR
• Long gene name
  ATR serine/threonine kinase
• Synonyms gene name
  • ataxia telangiectasia and Rad3 related
• Synonyms
  • FRP1
  • SCKL
  • SCKL1
  • MEC1
• Synonyms name
  • MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae)
• GenBank acession
  • U76308
• Locus
  3q23
• Discovery year
  1998-04-06
• Entrez gene record
  545
• Pubmed identfication
  • 8978690
  • 8610130
• RefSeq identity
  • NM_001184
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000159234
• Locus Specific Databases
  • LRG_1403

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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