Rabbit Anti Human ATR Antibody-Non-conjugated
-
Catalog numberCSB-PA622666LA01HU_100ug
-
PricePlease ask
-
Size100ug
-
-
Long nameRabbit Antibody against Human ATR, Non-conjugated
-
Synonym nameATR Human Antibody
-
Species reactivityHuman
-
Tested applications recommended dilutionsELISA,IHC;Recommended dilution:IHC:1:20-1:200
-
ConjugationNon-conjugated
-
Antibody isotypeIgG
-
UniProt IDQ13535
-
FormatLiquid, diluted in buffer
-
Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
-
Purity>95%
-
Purification methodProtein G purified
-
Antibody categoryPolyclonal Antibodies
-
Immunogen typeRecombinant human Serine/threonine-protein kinase ATR protein (2405-2644AA)
-
Immunogen speciesHuman
-
AliasSerine/threonine-protein kinase ATR,Ataxia telangiectasia and Rad3-related protein,FRAP-related protein 1,ATR,FRP1
-
BackgroundSerine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
-
ClonalityPolyclonal antibody
-
Shipping and storageATR Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
-
Short name of the antigenSerine/threonine-protein kinase ATR
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
-
PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
-
Latin nameOryctolagus cuniculus
-
French translationanticorps
-
Gene target
-
Gene symbolANTXR1, SERPINA2, ATR
-
Short nameAnti-ATR
-
Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
-
HostRabbit, Rabbits
-
SpeciesHuman, Humans
-
Alternative nameATR Antibody
-
Alternative techniqueantibodies, rabbit-anti
-
Alternative to gene targetataxia telangiectasia and Rad3 related, FCTCS and FRP1 and MEC1 and SCKL and SCKL1, ATR and IDBG-59521 and ENSG00000175054 and 545, transferase activity, nuclei, Atr and IDBG-191646 and ENSMUSG00000032409 and 245000, ATR and IDBG-638174 and ENSBTAG00000011529 and 504869
-
Gene info
-
Identity
-
Gene
-
Long gene nameANTXR cell adhesion molecule 1
-
Synonyms gene name
- anthrax toxin receptor 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2003-08-27
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- MicroRNA protein coding host genes
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameserpin family A member 2 (gene/pseudogene)
-
Synonyms gene
-
Synonyms gene name
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2, pseudogene
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-06-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Serpin peptidase inhibitors
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameATR serine/threonine kinase
-
Synonyms gene name
- ataxia telangiectasia and Rad3 related
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1998-04-06
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Armadillo like helical domain containing
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
