Levomefolic acid

• Description :

  Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements[1][2].

• Product Name Alternative :

  L-5-MTHF

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  DNA/RNA Synthesis; Endogenous Metabolite; Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/Levomefolic-acid.html

• Purity :

  98.55

• Solubility :

  DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 2.08 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NC[C@@H]2N(C)C3=C(NC(N)=NC3=O)NC2)C=C1)=O

• Molecular Formula :

  C20H25N7O6

• Molecular Weight :

  459.46

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Manisha Prajapat, et al. Virtual screening and molecular dynamics study of approved drugs as inhibitors of spike protein S1 domain and ACE2 interaction in SARS-CoV-2. J Mol Graph Model. 2020 Dec;101:107716.|[2] Maša Vidmar Golja, et al. Simultaneous quantification of intracellular concentrations of clinically important metabolites of folate-homocysteine cycle by LC-MS/MS. Anal Biochem. 2020 Sep 15;605:113830.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Citation 01 :

  Naunyn Schmiedebergs Arch Pharmacol. 2025 Nov 18.|Oncogene. 2025 May;44 (16) :1078-1092.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.

• CAS Number :

  [31690-09-2]