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CD437-13C6

CAT: 0804-HY-100532S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100532S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD437-13C6 is the 13C- and deuterium labeled CD437. CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.
Product Name Alternative
AHPN-13C6
UNSPSC
12352005
Target
Autophagy; Isotope-Labeled Compounds; RAR/RXR
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cd437-13c6.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C2C=C([13C]3=[13CH][13CH]=[13C](O)[13C](C4(C5)CC6CC5CC(C6)C4)=[13CH]3)C=CC2=C1)O
Molecular Formula
C21 13C6H26O3
Molecular Weight
404.45
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.|[2]Li Y, et al. Molecular determinants of AHPN (CD437) -induced growth arrest and apoptosis in human lung cancer cell lines. Mol Cell Biol. 1998 Aug;18 (8) :4719-31.|[3]Schadendorf D, et al. Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo. J Cell Biol. 1996 Dec;135 (6 Pt 2) :1889-98.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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