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Crystallin-αC rabbit pAb

CAT: 0855-ES20776-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20776-01Size:50 µL
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Background
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008],
Product Name Alternative
HSPB8; CRYAC; E2IG1; HSP22; PP1629; Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22
UniProt
Q9UJY1
Swiss Prot
Q9UJY1
Reactivity
Human
Immunogen
Recombinant Protein of Crystallin-αC
Target
HSPB8
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Dilution
WB: 1:500-1000
Buffer
-20°C/1 year
Molecular Weight
22kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
22kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.
Other Product Names
HSPB8; CRYAC; E2IG1; HSP22; PP1629; Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22
Gene ID (Human)
26353

UniProtKB · Q9UJY1

Heat shock protein beta-8

HSPB8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UJY1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HSPB8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HspB8
EC number
—
Processing
—
Secondary accessions
B2R6A6, Q6FIH3, Q9UKS3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Chaperone

Disease

Charcot-Marie-Tooth diseaseDisease variantMyofibrillar myopathyNeurodegenerationNeuropathy

Cellular component

CytoplasmNucleus

PTM

MethylationPhosphoprotein

Biological process

Stress response

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